Synthesis of pyridines by carbenoid-mediated ring opening of 2H-azirines

• Main Authors: Singh, Alok, Xu, Xianxiu, Park, Cheol-Min, Loy, Nicole S. Y.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: Chemistry and Biological Chemistry
• Online Access: https://hdl.handle.net/10356/99724; http://hdl.handle.net/10220/17532
• Institution: Nanyang Technological University

Roaming the range: The title reaction tolerates a wide range of substituents on the resulting pyridine ring using mild reaction conditions (see scheme; esp=α,α,α′,α′-tetramethyl-1,3-benzenedipropionic acid). The formation of the key intermediate is catalyst-controlled, and subsequent cyclization and...