Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase

Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase

Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3′-diazeniumdiolates as biofilm-targeted NO-...

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Main Authors: Rice, Scott A., Kardak, Bharat G., Kelso, Michael J., Yepuri, Nageshwar Rao, Barraud, Nicolas, Mohammadi, Nasim Shah, Kjelleberg, Staffan
Format: Article
Language:English
Published: 2013
Subjects:
Biofilms
Online Access:https://hdl.handle.net/10356/99731
http://hdl.handle.net/10220/17528
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-997312020-03-07T12:47:10Z Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase Rice, Scott A. Kardak, Bharat G. Kelso, Michael J. Yepuri, Nageshwar Rao Barraud, Nicolas Mohammadi, Nasim Shah Kjelleberg, Staffan Biofilms Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3′-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme β-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro. 2013-11-08T07:50:29Z 2019-12-06T20:10:49Z 2013-11-08T07:50:29Z 2019-12-06T20:10:49Z 2013 2013 Journal Article Yepuri, N. R., Barraud, N., Mohammadi, N. S., Kardak, B. G., Kjelleberg, S., Rice, S. A., et al. (2013). Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase. Chemical communications, 49(42), 4791-4793. https://hdl.handle.net/10356/99731 http://hdl.handle.net/10220/17528 10.1039/c3cc40869h en Chemical communications
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Biofilms
spellingShingle Biofilms
Rice, Scott A.
Kardak, Bharat G.
Kelso, Michael J.
Yepuri, Nageshwar Rao
Barraud, Nicolas
Mohammadi, Nasim Shah
Kjelleberg, Staffan
Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase
description Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3′-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme β-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro.
format Article
author Rice, Scott A.
Kardak, Bharat G.
Kelso, Michael J.
Yepuri, Nageshwar Rao
Barraud, Nicolas
Mohammadi, Nasim Shah
Kjelleberg, Staffan
author_facet Rice, Scott A.
Kardak, Bharat G.
Kelso, Michael J.
Yepuri, Nageshwar Rao
Barraud, Nicolas
Mohammadi, Nasim Shah
Kjelleberg, Staffan
author_sort Rice, Scott A.
title Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase
title_short Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase
title_full Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase
title_fullStr Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase
title_full_unstemmed Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase
title_sort synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing no-donor prodrugs activated by β-lactamase
publishDate 2013
url https://hdl.handle.net/10356/99731
http://hdl.handle.net/10220/17528
_version_ 1681042890068852736

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