Benzofuran-based estrogen receptor α modulators as anti-cancer therapeutics : in silico and experimental studies

• Main Authors: Leow, Min Li, Chin, Christina Hui Li, Yu, Peggy Shuang, Pasunooti, Kalyan Kumar, Tay, Raymond Xu Zhan, Zhang, Dawei, Yoon, Ho Sup, Liu, Xue-Wei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Chemistry::Biochemistry
• Online Access: https://hdl.handle.net/10356/99750; http://hdl.handle.net/10220/17385
• Institution: Nanyang Technological University

In the search for new estrogen receptor alpha (ERα) modulators, a trial molecular screening was conducted and 5,6-dihydroxybenzofuran was identified as a possible drug target for ERα. The target molecular modelling molecule 1 and a series of 5,6-dihydroxybenzofurans have been synthesized and evaluat...