Ternary dispersions to enhance solubility of poorly water soluble antioxidants

The main aim of this study was to enhance the solubility and dissolution rate of the two poorly water-soluble antioxidants, curcumin (CUR) and hesperetin (HSP). Binary dispersions of the two drugs in the polymer, polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG) matrix were prepared. A surfact...

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Main Authors: Kakran, Mitali, Sahoo, Nanda Gopal, Tan, Yong Wah, Li, Lin
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2013
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Online Access:https://hdl.handle.net/10356/99780
http://hdl.handle.net/10220/17612
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-997802020-03-07T13:22:19Z Ternary dispersions to enhance solubility of poorly water soluble antioxidants Kakran, Mitali Sahoo, Nanda Gopal Tan, Yong Wah Li, Lin School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering::Fluid mechanics The main aim of this study was to enhance the solubility and dissolution rate of the two poorly water-soluble antioxidants, curcumin (CUR) and hesperetin (HSP). Binary dispersions of the two drugs in the polymer, polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG) matrix were prepared. A surfactant (Pluronic F127 or Tween 80) was also combined with the polymer to develop ternary solid dispersions to further improve the dissolution properties of CUR and HSP. The FTIR study suggested hydrogen bonding between PVP and the drugs and minor intermolecular interactions between PEG and drugs. PVP showed better amorphizing nature than PEG as inferred from the DSC and XRD study. The surfactants added in the ternary dispersions further enhanced the intermolecular interaction of the polymers with the drugs. The 2D micro-Raman spectroscopic mapping showed that after adding the surfactants in the ternary dispersions, CUR and HSP were more uniformly distributed in the PEG matrix. The solubility and dissolution rates of CUR and HSP were increased by dispersing them in the polymer matrix and the increase was dramatic when the surfactant was added to the dispersion system. The intermolecular interactions between drug and carriers led to better dispersion of drug in the polymer matrix and reduction in the size of drug particles; increase in the amorphous nature, decrease in surface tension and increase in the wettability which resulted in enhanced solubility and dissolution of the ternary dispersions. The ternary dispersions also presented better long term stability in terms of the amorphous nature and the dissolution properties. 2013-11-12T08:23:09Z 2019-12-06T20:11:20Z 2013-11-12T08:23:09Z 2019-12-06T20:11:20Z 2013 2013 Journal Article Kakran, M., Sahoo, N. G., Tan, Y. W., & Li, L. (2013). Ternary dispersions to enhance solubility of poorly water soluble antioxidants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 433, 111-121. 0927-7757 https://hdl.handle.net/10356/99780 http://hdl.handle.net/10220/17612 10.1016/j.colsurfa.2013.05.021 en Colloids and surfaces A: physicochemical and engineering aspects
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Engineering::Mechanical engineering::Fluid mechanics
spellingShingle DRNTU::Engineering::Mechanical engineering::Fluid mechanics
Kakran, Mitali
Sahoo, Nanda Gopal
Tan, Yong Wah
Li, Lin
Ternary dispersions to enhance solubility of poorly water soluble antioxidants
description The main aim of this study was to enhance the solubility and dissolution rate of the two poorly water-soluble antioxidants, curcumin (CUR) and hesperetin (HSP). Binary dispersions of the two drugs in the polymer, polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG) matrix were prepared. A surfactant (Pluronic F127 or Tween 80) was also combined with the polymer to develop ternary solid dispersions to further improve the dissolution properties of CUR and HSP. The FTIR study suggested hydrogen bonding between PVP and the drugs and minor intermolecular interactions between PEG and drugs. PVP showed better amorphizing nature than PEG as inferred from the DSC and XRD study. The surfactants added in the ternary dispersions further enhanced the intermolecular interaction of the polymers with the drugs. The 2D micro-Raman spectroscopic mapping showed that after adding the surfactants in the ternary dispersions, CUR and HSP were more uniformly distributed in the PEG matrix. The solubility and dissolution rates of CUR and HSP were increased by dispersing them in the polymer matrix and the increase was dramatic when the surfactant was added to the dispersion system. The intermolecular interactions between drug and carriers led to better dispersion of drug in the polymer matrix and reduction in the size of drug particles; increase in the amorphous nature, decrease in surface tension and increase in the wettability which resulted in enhanced solubility and dissolution of the ternary dispersions. The ternary dispersions also presented better long term stability in terms of the amorphous nature and the dissolution properties.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Kakran, Mitali
Sahoo, Nanda Gopal
Tan, Yong Wah
Li, Lin
format Article
author Kakran, Mitali
Sahoo, Nanda Gopal
Tan, Yong Wah
Li, Lin
author_sort Kakran, Mitali
title Ternary dispersions to enhance solubility of poorly water soluble antioxidants
title_short Ternary dispersions to enhance solubility of poorly water soluble antioxidants
title_full Ternary dispersions to enhance solubility of poorly water soluble antioxidants
title_fullStr Ternary dispersions to enhance solubility of poorly water soluble antioxidants
title_full_unstemmed Ternary dispersions to enhance solubility of poorly water soluble antioxidants
title_sort ternary dispersions to enhance solubility of poorly water soluble antioxidants
publishDate 2013
url https://hdl.handle.net/10356/99780
http://hdl.handle.net/10220/17612
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