Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein
A series of 5-substituted 2-pyrrolidinones was synthesized through a one-pot ruthenium alkylidene-catalyzed tandem RCM/isomerization/nucleophilic addition sequence. The intermediates resulting from RCM/isomerization showed reactivity toward electrophiles in aldol condensation reactions which provide...
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sg-ntu-dr.10356-998172020-03-07T12:47:10Z Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein Petersen, Mette T. Nielsen, Thomas E. School of Biological Sciences DRNTU::Science::Biological sciences A series of 5-substituted 2-pyrrolidinones was synthesized through a one-pot ruthenium alkylidene-catalyzed tandem RCM/isomerization/nucleophilic addition sequence. The intermediates resulting from RCM/isomerization showed reactivity toward electrophiles in aldol condensation reactions which provided a new entry for the total synthesis of the antileukemic natural product violacein. 2013-11-19T04:00:21Z 2019-12-06T20:11:56Z 2013-11-19T04:00:21Z 2019-12-06T20:11:56Z 2013 2013 Journal Article Petersen, M. T., & Nielsen, T. E. (2013). Tandem Ring-Closing Metathesis/Isomerization Reactions for the Total Synthesis of Violacein. Organic Letters, 15(8), 1986-1989. https://hdl.handle.net/10356/99817 http://hdl.handle.net/10220/17769 10.1021/ol400654r en Organic letters |
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DRNTU::Science::Biological sciences |
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DRNTU::Science::Biological sciences Petersen, Mette T. Nielsen, Thomas E. Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| description |
A series of 5-substituted 2-pyrrolidinones was synthesized through a one-pot ruthenium alkylidene-catalyzed tandem RCM/isomerization/nucleophilic addition sequence. The intermediates resulting from RCM/isomerization showed reactivity toward electrophiles in aldol condensation reactions which provided a new entry for the total synthesis of the antileukemic natural product violacein. |
| author2 |
School of Biological Sciences |
| author_facet |
School of Biological Sciences Petersen, Mette T. Nielsen, Thomas E. |
| format |
Article |
| author |
Petersen, Mette T. Nielsen, Thomas E. |
| author_sort |
Petersen, Mette T. |
| title |
Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| title_short |
Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| title_full |
Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| title_fullStr |
Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| title_full_unstemmed |
Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| title_sort |
tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/99817 http://hdl.handle.net/10220/17769 |
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1681045236197883904 |