Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein

• Main Authors: Petersen, Mette T., Nielsen, Thomas E.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/99817; http://hdl.handle.net/10220/17769
• Institution: Nanyang Technological University

A series of 5-substituted 2-pyrrolidinones was synthesized through a one-pot ruthenium alkylidene-catalyzed tandem RCM/isomerization/nucleophilic addition sequence. The intermediates resulting from RCM/isomerization showed reactivity toward electrophiles in aldol condensation reactions which provide...