Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice

Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice

10.1007/s00109-011-0746-2

Saved in:

Bibliographic Details
Main Authors:	Shanmugam, M.K., Rajendran, P., Li, F., Nema, T., Vali, S., Abbasi, T., Kapoor, S., Sharma, A., Kumar, A.P., Ho, P.C., Hui, K.M., Sethi, G.
Other Authors:	PHARMACOLOGY
Format:	Article
Published:	2014
Subjects:	NF-κB Prostate cancer STAT3 Ursolic acid
Online Access:	http://scholarbank.nus.edu.sg/handle/10635/108591
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

Similar Items

Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies
by: Shanmugam, M.K., et al.
Published: (2014)

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model
by: Shanmugam, M.K., et al.
Published: (2014)

Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products
by: Manu, K.A., et al.
Published: (2014)

Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
by: Kannaiyan, R., et al.
Published: (2014)

IDENTIFICATION OF A NOVEL AGENT THAT CAN SUPPRESS PROLIFERATION, INDUCE APOPTOSIS AND OVERCOME CHEMORESISTANCE IN MULTIPLE MYELOMA
by: RADHAMANI KANNAIYAN
Published: (2014)

TARGETED INHIBITION OF CONSTITUTIVE AND INTERLEUKIN-6-INDUCIBLE STAT3 SIGNALING CASCADE FOR THE PREVENTION AND TREATMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA
by: LI FENG
Published: (2015)

Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6/STAT3 and Aurora kinase A pathways in TRAMP mice
by: Sun, Feng, et al.
Published: (2021)

Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells
by: Chua, A.W.L., et al.
Published: (2014)

Role of NF-κB in tumorigenesis
by: Shanmugam, M.K., et al.
Published: (2014)

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer
by: Prasannan, R., et al.
Published: (2014)

THE POTENTIAL ROLE OF NIMBOLIDE IN THE PREVENTION AND TREATMENT OF PROSTATE CANCER
by: ZHANG JINGWEN
Published: (2016)

GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat
by: Li, L., et al.
Published: (2012)

Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy
by: Li, F., et al.
Published: (2011)

The Role of Serum Amyloid A in atherosclerosis
by: TAN SI ZHEN
Published: (2012)

Chrysin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB
by: Li, X., et al.
Published: (2011)

Is transurethral needle ablation of prostate out of fashion? Outcomes of single session office-based transurethral needle ablation of prostate in patients with symptomatic benign prostatic hyperplasia
by: Law, Y.X.T., et al.
Published: (2021)

Multifaceted link between cancer and inflammation
by: Sethi, G., et al.
Published: (2014)

Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation
by: Won, M., et al.
Published: (2014)

Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression
by: Ling, H., et al.
Published: (2014)

RANKL targeted peptides inhibit osteoclastogenesis and attenuate adjuvant induced arthritis by inhibiting NF-κB activation and down regulating inflammatory cytokines
by: Naidu, V.G.M., et al.
Published: (2014)

Review of clinical manifestations of biochemically-advanced prostate cancer cases
by: Chiong, E., et al.
Published: (2011)

Is seminal prostatic acid phosphatase a reliable marker for male infertility?
by: Singh, G., et al.
Published: (2013)

The combined role of MRI prostate and prostate health index in improving detection of significant prostate cancer in a screening population of Chinese men
by: Chiu, Peter K. F., et al.
Published: (2024)

A community based study of prostatic symptoms in Singapore
by: Tan, H.Y., et al.
Published: (2011)

Monte Carlo N-particle (MCNP) simulation of prostate cancer brachytherapy with edema and I-125 seed displacement
by: Almanza, Dustin Lorenz V.
Published: (2018)

Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-B: Implication in breast cancer metastasis
by: Bist, P., et al.
Published: (2014)

ARTESUNATE SUPPRESSES TUMOR GROWTH AND PROGRESSION OF PROSTRATE CANCER THROUGH THE MODULATION OF STAT3 AND NF-kB SIGNALING CASCADES
by: ALAMELU NACHIYAPPAN
Published: (2016)

Transcriptional regulation during aberrant activation of NF-κB signalling in cancer
by: Deka, Kamalakshi, et al.
Published: (2023)

Effect of mitogen-activated protein kinases on chemokine synthesis induced by substance P in mouse pancreatic acinar cells
by: Ramnath, R.D., et al.
Published: (2011)

The usefulness of serum free/total PSA ratio for diagnosis of prostate cancer in abnormal total PSA screening Thai patients
by: Sansnee Senawong
Published: (2009)

Mutations which abolish phosphorylation of the TRAF-binding domain of TNF receptor 2 enhance receptor-mediated NF-κB activation
by: Ng, P.W.P., et al.
Published: (2014)

Transurethral incision of the prostate (TUIP) compared to transurethral resection of the prostate (TURP) in treating benign prostatic hyperplasia (BPH) patients with estimated prostatic weight of 50 grams or less : a randomized controlled trial
by: Kriangsak Prasopsanti
Published: (2009)

A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways
by: Gan, F.-F., et al.
Published: (2014)

Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel
by: Lee, J.H, et al.
Published: (2020)

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
by: Sethi, G., et al.
Published: (2014)

Trefoil factor 1 suppression of E-CADHERIN enhances prostate carcinoma cell invasiveness and metastasis
by: Bougen, N.M., et al.
Published: (2014)

Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
by: Subramaniam, A., et al.
Published: (2014)

MHC class II-associated invariant chain (Ii) modulates dendritic cells-derived microvesicles (DCMV)-mediated activation of microglia
by: Teo, B.H.D., et al.
Published: (2014)

Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways
by: Shanmugam, M.K., et al.
Published: (2014)

An analysis of concordant xenograft rejection in the nude rat model
by: Lim, S.M.L., et al.
Published: (2016)