Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

• Main Authors: Lee, J.H, Kim, C, Sethi, G, Ahn, K.S
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: brassinin; CD31 antigen; interleukin 6; Ki 67 antigen; paclitaxel; phytoalexin; PIAS 3; protein inhibitor of activated STAT; small interfering RNA; STAT3 protein; suppressor of cytokine signaling 3; unclassified drug; chaperone; indole derivative; PIAS3 protein, human; SOCS3 protein, human; STAT3 protein, human; suppressor of cytokine signaling; thiocarbamic acid derivative; animal experiment; animal model; animal tissue; apoptosis; Article; cancer cell; carcinogenesis; cell invasion; cell proliferation; cell viability; controlled study; down regulation; drug cytotoxicity; drug sensitization; drug structure; female; gene induction; gene product; gene silencing; human; human cell; mouse; mouse model; non small cell lung cancer; nonhuman; nude mouse; protein expression; protein induction; protein phosphorylation; signal transduction; tumor growth; tumor xenograft; animal; antagonists and inhibitors; drug effects; drug screening; genetic transfection; K-562 cell line; male; metabolism; randomization; tumor cell line; Animals; Cell Line, Tumor; Cell Proliferation; Humans; Indoles; K562 Cells; Male; Mice; Mice, Nude; Molecular Chaperones; Paclitaxel; Protein Inhibitors of Activated STAT; Random Allocation; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thiocarbamates; Transfection; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/177761
• Institution: National University of Singapore

10.18632/oncotarget.3443