Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

10.1186/1476-4598-10-107

Saved in:

Bibliographic Details
Main Authors:	Manu, K.A., Shanmugam, M.K., Rajendran, P., Li, F., Ramachandran, L., Hay, H.S., Kannaiyan, R., Swamy, S.N., Vali, S., Kapoor, S., Ramesh, B., Bist, P., Koay, E.S., Lim, L.H.K., Ahn, K.S., Kumar, A.P., Sethi, G.
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2014
Online Access:	http://scholarbank.nus.edu.sg/handle/10635/109520
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

Similar Items

Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells
by: Chua, A.W.L., et al.
Published: (2014)

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model
by: Shanmugam, M.K., et al.
Published: (2014)

Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma
by: Manu, K.A., et al.
Published: (2014)

The chemokine Sdf-1 and its receptor Cxcr4 are required for formation of muscle in zebrafish
by: Chong, S.-W., et al.
Published: (2014)

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1
by: Rajendran, P., et al.
Published: (2014)

The anthelmintic effect of plumbagin on Schistosoma mansoni
by: Natcha Lorsuwannarat, et al.
Published: (2018)

Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
by: Kannaiyan, R., et al.
Published: (2014)

An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins
by: Subramaniam, A., et al.
Published: (2014)

Production of human embryonic kidney 293T cells stably expressing C-X-C chemokine receptor type 4 (CXCR4) as a screening tool for anticancer lead compound targeting CXCR4
by: Dinh Thi Thai Ha, et al.
Published: (2022)

Production of human embryonic kidney 293T cells stably expressing C-X-C chemokine receptor type 4 (CXCR4) as a screening tool for anticancer lead compound targeting CXCR4
by: Ha D.T.T.
Published: (2023)

Chemokine stromal cell-derived factor-1 and its receptor CXCR4 mediate migration of marrow stromal cells into the lesion site of completely transected spinal cord
by: Ding, P., et al.
Published: (2015)

Plumbagin Suppresses Breast Cancer Progression by Downregulating HIF-1α Expression via a PI3K/Akt/mTOR Independent Pathway under Hypoxic Condition
by: Jampasri S.
Published: (2023)

Plumbagin production in cell suspension cultures of Plumbago zeylanica L.
by: Orasa Choosakul
Published: (2007)

Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
by: Li F., et al.
Published: (2020)

Expression of chemokine receptors CXCR4, CCR2, CCR5 and CX3CR1 in neural progenitor cells isolated from the subventricular zone of the adult rat brain
by: Ji, J.F., et al.
Published: (2012)

Paramphistomum cervi: The in vitro effect of plumbagin on motility, survival and tegument structure
by: Naruwan Saowakon, et al.
Published: (2018)

Expression pattern of two zebrafish genes, cxcr4a and cxcr4b
by: Chong, S.W., et al.
Published: (2014)

Identification of matrine as a novel regulator of the CXCR4 signaling axis in tumor cells
by: Jung, Y.Y., et al.
Published: (2021)

Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer
by: Ramachandran, L., et al.
Published: (2014)

Nematicidal effect of plumbagin on Caenorhabditis elegans: A model for testing a nematicidal drug
by: Phantip Chaweeborisuit, et al.
Published: (2018)

Targeting cell signaling and apoptotic pathways by dietary agents: Role in the prevention and treatment of cancer
by: Shanmugam, M.K., et al.
Published: (2014)

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer
by: Kannaiyan, R., et al.
Published: (2014)

Chemokines in acute respiratory distress syndrome
by: Puneet, P., et al.
Published: (2014)

Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis
by: Shanmugam, Muthu K, et al.
Published: (2022)

The prenylflavonoid Icaritin enhances osteoblast proliferation and function by signal transducer and activator of transcription factor 3 (STAT-3) regulation of C-X-C chemokine receptor type 4 (CXCR4) expression
by: Lim, RZL, et al.
Published: (2021)

Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
by: Shanmugam, M.K., et al.
Published: (2014)

Cytokines and Chemokines in Periodontitis
by: Doaa Elsayed Ramadan, -, et al.
Published: (2020)

The in vitro anthelmintic effects of plumbagin on newly excysted and 4-weeks-old juvenile parasites of Fasciola gigantica
by: Natcha Lorsuwannarat, et al.
Published: (2018)

Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils
by: Sun, J., et al.
Published: (2011)

Increase in activated CD4+ lymphocytes with CCR5 and CXCR4 in HIV type 1-infected persons
by: P. Auewarakul, et al.
Published: (2018)

Human cytomegalovirus clinical strain-specific microRNA miR-UL148D targets the human chemokine RANTES during infection
by: Kim Y., et al.
Published: (2018)

Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo
by: Rajendran, P., et al.
Published: (2014)

Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
by: Shanmugam, M.K, et al.
Published: (2020)

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma
by: Lee, J.H., et al.
Published: (2021)

Cytokine and chemokine responses in a cerebral malaria-susceptible or -resistant strain of mice to Plasmodium berghei ANKA infection: Early chemokine expression in the brain
by: Syarifah P. Hanum, et al.
Published: (2018)

MYC is downregulated by a mitochondrial checkpoint mechanism
by: Zhang, X, et al.
Published: (2020)

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
by: Kannaiyan, R., et al.
Published: (2014)

ANTI-CANCER EFFECTS, MECHANISM OF ACTION AND COMBINATION THERAPEUTICS OF PLUMBAGIN, A NATURAL PLANT PRODUCT, IN BREAST CANCER CELLS
by: SAFOURA SAMENI
Published: (2014)

Cytokines and chemokines in irritant contact dermatitis
by: Lee, H.Y, et al.
Published: (2020)

Suppression of essential pro-inflammatory signaling pathways by natural agents for the therapy of multiple myeloma
by: Sikka, S., et al.
Published: (2014)