Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma

• Main Authors: Shanmugam, M.K, Ahn, K.S, Lee, J.H, Kannaiyan, R, Mustafa, N, Manu, K.A, Siveen, K.S, Sethi, G, Chng, W.J, Kumar, A.P
• Other Authors: PHARMACOLOGY
• Format: Article
• Published: 2020
• Subjects: bortezomib; caspase 3; celastrol; chemokine receptor CXCR4; gelatinase B; immunoglobulin enhancer binding protein; interleukin 6; syndecan 1; tumor necrosis factor; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; apoptosis; Article; cell invasion; cell migration; cell proliferation; controlled study; CXCR4 gene; drug effect; drug structure; enzyme activation; enzyme repression; gene product; human; human cell; human tissue; in vitro study; in vivo study; male; MMP 9 gene; mouse; multiple myeloma; nonhuman; protein blood level; protein expression; tumor growth; tumor xenograft; upregulation
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175386
• Institution: National University of Singapore

10.3389/fphar.2018.00365