Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model

10.18632/oncotarget.1596

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Bibliographic Details
Main Authors:	Siveen, K.S, Mustafa, N, Li, F, Kannaiyan, R, Ahn, K.S, Kumar, A.P, Chng, W.-J, Sethi, G
Other Authors:	PHARMACOLOGY
Format:	Article
Published:	Impact Journals LLC 2020
Subjects:	bortezomib caspase 3 chemokine receptor CXCR4 cyclooxygenase 2 doxorubicin gelatinase B immunoglobulin enhancer binding protein interleukin 6 Ki 67 antigen melphalan nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein bcl 2 syndecan 1 thymoquinone transcription factor RelA tumor necrosis factor alpha vasculotropin antineoplastic agent benzoquinone derivative boronic acid derivative pyrazine derivative animal experiment animal model animal tissue antineoplastic activity antiproliferative activity apoptosis article Bcl 2 gene cancer cell culture cancer inhibition cancer resistance cell isolation concentration response controlled study cox2 gene CXCR4 gene drug potentiation drug sensitivity enzyme activation gene disruption gene product human human cell IL 6 gene in vitro study in vivo study ki 67 gene male migration inhibition MMP9 gene mouse multiple myeloma myeloma cell nonhuman p65 gene protein cleavage protein expression TNFalpha gene tumor invasion tumor xenograft VEGF gene animal Bagg albino mouse cell proliferation disease model drug effects drug screening genetics metabolism nude mouse pathology randomization signal transduction tumor cell line Animals Antineoplastic Combined Chemotherapy Protocols Apoptosis Benzoquinones Boronic Acids Cell Line, Tumor Cell Proliferation Disease Models, Animal Drug Synergism Humans Male Mice Mice, Inbred BALB C Mice, Nude Multiple Myeloma NF-kappa B Pyrazines Random Allocation Signal Transduction Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175000
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Institution:	National University of Singapore

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https://scholarbank.nus.edu.sg/handle/10635/175000