Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model

• Main Authors: Siveen, K.S, Mustafa, N, Li, F, Kannaiyan, R, Ahn, K.S, Kumar, A.P, Chng, W.-J, Sethi, G
• Other Authors: PHARMACOLOGY
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: bortezomib; caspase 3; chemokine receptor CXCR4; cyclooxygenase 2; doxorubicin; gelatinase B; immunoglobulin enhancer binding protein; interleukin 6; Ki 67 antigen; melphalan; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; protein bcl 2; syndecan 1; thymoquinone; transcription factor RelA; tumor necrosis factor alpha; vasculotropin; antineoplastic agent; benzoquinone derivative; boronic acid derivative; pyrazine derivative; animal experiment; animal model; animal tissue; antineoplastic activity; antiproliferative activity; apoptosis; article; Bcl 2 gene; cancer cell culture; cancer inhibition; cancer resistance; cell isolation; concentration response; controlled study; cox2 gene; CXCR4 gene; drug potentiation; drug sensitivity; enzyme activation; gene disruption; gene product; human; human cell; IL 6 gene; in vitro study; in vivo study; ki 67 gene; male; migration inhibition; MMP9 gene; mouse; multiple myeloma; myeloma cell; nonhuman; p65 gene; protein cleavage; protein expression; TNFalpha gene; tumor invasion; tumor xenograft; VEGF gene; animal; Bagg albino mouse; cell proliferation; disease model; drug effects; drug screening; genetics; metabolism; nude mouse; pathology; randomization; signal transduction; tumor cell line; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzoquinones; Boronic Acids; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Synergism; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Multiple Myeloma; NF-kappa B; Pyrazines; Random Allocation; Signal Transduction; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175000
• Institution: National University of Singapore

10.18632/oncotarget.1596