Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model

10.18632/oncotarget.1596

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Main Authors:	Siveen, K.S, Mustafa, N, Li, F, Kannaiyan, R, Ahn, K.S, Kumar, A.P, Chng, W.-J, Sethi, G
Other Authors:	PHARMACOLOGY
Format:	Article
Published:	Impact Journals LLC 2020
Subjects:	bortezomib caspase 3 chemokine receptor CXCR4 cyclooxygenase 2 doxorubicin gelatinase B immunoglobulin enhancer binding protein interleukin 6 Ki 67 antigen melphalan nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein bcl 2 syndecan 1 thymoquinone transcription factor RelA tumor necrosis factor alpha vasculotropin antineoplastic agent benzoquinone derivative boronic acid derivative pyrazine derivative animal experiment animal model animal tissue antineoplastic activity antiproliferative activity apoptosis article Bcl 2 gene cancer cell culture cancer inhibition cancer resistance cell isolation concentration response controlled study cox2 gene CXCR4 gene drug potentiation drug sensitivity enzyme activation gene disruption gene product human human cell IL 6 gene in vitro study in vivo study ki 67 gene male migration inhibition MMP9 gene mouse multiple myeloma myeloma cell nonhuman p65 gene protein cleavage protein expression TNFalpha gene tumor invasion tumor xenograft VEGF gene animal Bagg albino mouse cell proliferation disease model drug effects drug screening genetics metabolism nude mouse pathology randomization signal transduction tumor cell line Animals Antineoplastic Combined Chemotherapy Protocols Apoptosis Benzoquinones Boronic Acids Cell Line, Tumor Cell Proliferation Disease Models, Animal Drug Synergism Humans Male Mice Mice, Inbred BALB C Mice, Nude Multiple Myeloma NF-kappa B Pyrazines Random Allocation Signal Transduction Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175000
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1750002024-11-12T22:45:30Z Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model Siveen, K.S Mustafa, N Li, F Kannaiyan, R Ahn, K.S Kumar, A.P Chng, W.-J Sethi, G PHARMACOLOGY MEDICINE CANCER SCIENCE INSTITUTE OF SINGAPORE bortezomib caspase 3 chemokine receptor CXCR4 cyclooxygenase 2 doxorubicin gelatinase B immunoglobulin enhancer binding protein interleukin 6 Ki 67 antigen melphalan nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein bcl 2 syndecan 1 thymoquinone transcription factor RelA tumor necrosis factor alpha vasculotropin antineoplastic agent benzoquinone derivative boronic acid derivative bortezomib immunoglobulin enhancer binding protein pyrazine derivative thymoquinone animal experiment animal model animal tissue antineoplastic activity antiproliferative activity apoptosis article Bcl 2 gene cancer cell culture cancer inhibition cancer resistance cell isolation concentration response controlled study cox2 gene CXCR4 gene drug potentiation drug sensitivity enzyme activation gene disruption gene product human human cell IL 6 gene in vitro study in vivo study ki 67 gene male migration inhibition MMP9 gene mouse multiple myeloma myeloma cell nonhuman p65 gene protein cleavage protein expression TNFalpha gene tumor invasion tumor xenograft VEGF gene animal Bagg albino mouse cell proliferation disease model drug effects drug potentiation drug screening genetics metabolism multiple myeloma nude mouse pathology randomization signal transduction tumor cell line Animals Antineoplastic Combined Chemotherapy Protocols Apoptosis Benzoquinones Boronic Acids Cell Line, Tumor Cell Proliferation Disease Models, Animal Drug Synergism Humans Male Mice Mice, Inbred BALB C Mice, Nude Multiple Myeloma NF-kappa B Pyrazines Random Allocation Signal Transduction Xenograft Model Antitumor Assays 10.18632/oncotarget.1596 Oncotarget 5 3 634-648 2020-09-09T02:58:12Z 2020-09-09T02:58:12Z 2014 Article Siveen, K.S, Mustafa, N, Li, F, Kannaiyan, R, Ahn, K.S, Kumar, A.P, Chng, W.-J, Sethi, G (2014). Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model. Oncotarget 5 (3) : 634-648. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.1596 19492553 https://scholarbank.nus.edu.sg/handle/10635/175000 Impact Journals LLC Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	bortezomib caspase 3 chemokine receptor CXCR4 cyclooxygenase 2 doxorubicin gelatinase B immunoglobulin enhancer binding protein interleukin 6 Ki 67 antigen melphalan nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein bcl 2 syndecan 1 thymoquinone transcription factor RelA tumor necrosis factor alpha vasculotropin antineoplastic agent benzoquinone derivative boronic acid derivative bortezomib immunoglobulin enhancer binding protein pyrazine derivative thymoquinone animal experiment animal model animal tissue antineoplastic activity antiproliferative activity apoptosis article Bcl 2 gene cancer cell culture cancer inhibition cancer resistance cell isolation concentration response controlled study cox2 gene CXCR4 gene drug potentiation drug sensitivity enzyme activation gene disruption gene product human human cell IL 6 gene in vitro study in vivo study ki 67 gene male migration inhibition MMP9 gene mouse multiple myeloma myeloma cell nonhuman p65 gene protein cleavage protein expression TNFalpha gene tumor invasion tumor xenograft VEGF gene animal Bagg albino mouse cell proliferation disease model drug effects drug potentiation drug screening genetics metabolism multiple myeloma nude mouse pathology randomization signal transduction tumor cell line Animals Antineoplastic Combined Chemotherapy Protocols Apoptosis Benzoquinones Boronic Acids Cell Line, Tumor Cell Proliferation Disease Models, Animal Drug Synergism Humans Male Mice Mice, Inbred BALB C Mice, Nude Multiple Myeloma NF-kappa B Pyrazines Random Allocation Signal Transduction Xenograft Model Antitumor Assays
spellingShingle	bortezomib caspase 3 chemokine receptor CXCR4 cyclooxygenase 2 doxorubicin gelatinase B immunoglobulin enhancer binding protein interleukin 6 Ki 67 antigen melphalan nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein bcl 2 syndecan 1 thymoquinone transcription factor RelA tumor necrosis factor alpha vasculotropin antineoplastic agent benzoquinone derivative boronic acid derivative bortezomib immunoglobulin enhancer binding protein pyrazine derivative thymoquinone animal experiment animal model animal tissue antineoplastic activity antiproliferative activity apoptosis article Bcl 2 gene cancer cell culture cancer inhibition cancer resistance cell isolation concentration response controlled study cox2 gene CXCR4 gene drug potentiation drug sensitivity enzyme activation gene disruption gene product human human cell IL 6 gene in vitro study in vivo study ki 67 gene male migration inhibition MMP9 gene mouse multiple myeloma myeloma cell nonhuman p65 gene protein cleavage protein expression TNFalpha gene tumor invasion tumor xenograft VEGF gene animal Bagg albino mouse cell proliferation disease model drug effects drug potentiation drug screening genetics metabolism multiple myeloma nude mouse pathology randomization signal transduction tumor cell line Animals Antineoplastic Combined Chemotherapy Protocols Apoptosis Benzoquinones Boronic Acids Cell Line, Tumor Cell Proliferation Disease Models, Animal Drug Synergism Humans Male Mice Mice, Inbred BALB C Mice, Nude Multiple Myeloma NF-kappa B Pyrazines Random Allocation Signal Transduction Xenograft Model Antitumor Assays Siveen, K.S Mustafa, N Li, F Kannaiyan, R Ahn, K.S Kumar, A.P Chng, W.-J Sethi, G Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model
description	10.18632/oncotarget.1596
author2	PHARMACOLOGY
author_facet	PHARMACOLOGY Siveen, K.S Mustafa, N Li, F Kannaiyan, R Ahn, K.S Kumar, A.P Chng, W.-J Sethi, G
format	Article
author	Siveen, K.S Mustafa, N Li, F Kannaiyan, R Ahn, K.S Kumar, A.P Chng, W.-J Sethi, G
author_sort	Siveen, K.S
title	Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model
title_short	Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model
title_full	Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model
title_fullStr	Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model
title_full_unstemmed	Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model
title_sort	thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of nf-?b regulated gene products in multiple myeloma xenograft mouse model
publisher	Impact Journals LLC
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175000
_version_	1821218164895121408

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-?B regulated gene products in multiple myeloma xenograft mouse model

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