Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)

• Main Authors: Huang, R.Y.-J, Kuay, K.T, Tan, T.Z, Asad, M, Tang, H.M, Chun Ng, A.H, Ye, J, Chung, V.Y, Thiery, J.P
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: 2020
• Subjects: nintedanib; saracatinib; small interfering RNA; transcription factor ZEB1; uvomorulin; antineoplastic agent; enzyme inhibitor; indole derivative; animal experiment; animal model; animal tissue; antineoplastic activity; Article; CD99L2 gene; cell proliferation; controlled study; cytotoxicity; down regulation; EMP3 gene; epithelial mesenchymal transition; female; gene; gene expression; gene identification; gene silencing; human; human cell; in vitro study; in vivo study; ITGA5 gene; mouse; nonhuman; ovarian cancer cell line; protein expression; SYDE1 gene; upregulation; VIM gene; ZEB1 gene; animal; Bagg albino mouse; drug effects; genetics; metabolism; nude mouse; Ovarian Neoplasms; pathology; treatment outcome; tumor cell line; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; Humans; Indoles; Mice; Mice, Inbred BALB C; Mice, Nude; Treatment Outcome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174142
• Institution: National University of Singapore

10.18632/oncotarget.4300