Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)

10.18632/oncotarget.4300

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Main Authors:	Huang, R.Y.-J, Kuay, K.T, Tan, T.Z, Asad, M, Tang, H.M, Chun Ng, A.H, Ye, J, Chung, V.Y, Thiery, J.P
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	nintedanib saracatinib small interfering RNA transcription factor ZEB1 uvomorulin antineoplastic agent enzyme inhibitor indole derivative animal experiment animal model animal tissue antineoplastic activity Article CD99L2 gene cell proliferation controlled study cytotoxicity down regulation EMP3 gene epithelial mesenchymal transition female gene gene expression gene identification gene silencing human human cell in vitro study in vivo study ITGA5 gene mouse nonhuman ovarian cancer cell line protein expression SYDE1 gene upregulation VIM gene ZEB1 gene animal Bagg albino mouse drug effects genetics metabolism nude mouse Ovarian Neoplasms pathology treatment outcome tumor cell line Animals Antineoplastic Agents Cell Line, Tumor Cell Proliferation Enzyme Inhibitors Epithelial-Mesenchymal Transition Female Humans Indoles Mice Mice, Inbred BALB C Mice, Nude Treatment Outcome
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174142
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1741422024-11-13T11:14:47Z Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120) Huang, R.Y.-J Kuay, K.T Tan, T.Z Asad, M Tang, H.M Chun Ng, A.H Ye, J Chung, V.Y Thiery, J.P CANCER SCIENCE INSTITUTE OF SINGAPORE DUKE-NUS MEDICAL SCHOOL BIOCHEMISTRY nintedanib saracatinib small interfering RNA transcription factor ZEB1 uvomorulin antineoplastic agent enzyme inhibitor indole derivative nintedanib animal experiment animal model animal tissue antineoplastic activity Article CD99L2 gene cell proliferation controlled study cytotoxicity down regulation EMP3 gene epithelial mesenchymal transition female gene gene expression gene identification gene silencing human human cell in vitro study in vivo study ITGA5 gene mouse nonhuman ovarian cancer cell line protein expression SYDE1 gene upregulation VIM gene ZEB1 gene animal Bagg albino mouse drug effects epithelial mesenchymal transition genetics metabolism nude mouse Ovarian Neoplasms pathology treatment outcome tumor cell line Animals Antineoplastic Agents Cell Line, Tumor Cell Proliferation Enzyme Inhibitors Epithelial-Mesenchymal Transition Female Humans Indoles Mice Mice, Inbred BALB C Mice, Nude Ovarian Neoplasms Treatment Outcome 10.18632/oncotarget.4300 Oncotarget 6 26 22098-22113 2020-09-03T10:37:40Z 2020-09-03T10:37:40Z 2015 Article Huang, R.Y.-J, Kuay, K.T, Tan, T.Z, Asad, M, Tang, H.M, Chun Ng, A.H, Ye, J, Chung, V.Y, Thiery, J.P (2015). Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120). Oncotarget 6 (26) : 22098-22113. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.4300 19492553 https://scholarbank.nus.edu.sg/handle/10635/174142 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	nintedanib saracatinib small interfering RNA transcription factor ZEB1 uvomorulin antineoplastic agent enzyme inhibitor indole derivative nintedanib animal experiment animal model animal tissue antineoplastic activity Article CD99L2 gene cell proliferation controlled study cytotoxicity down regulation EMP3 gene epithelial mesenchymal transition female gene gene expression gene identification gene silencing human human cell in vitro study in vivo study ITGA5 gene mouse nonhuman ovarian cancer cell line protein expression SYDE1 gene upregulation VIM gene ZEB1 gene animal Bagg albino mouse drug effects epithelial mesenchymal transition genetics metabolism nude mouse Ovarian Neoplasms pathology treatment outcome tumor cell line Animals Antineoplastic Agents Cell Line, Tumor Cell Proliferation Enzyme Inhibitors Epithelial-Mesenchymal Transition Female Humans Indoles Mice Mice, Inbred BALB C Mice, Nude Ovarian Neoplasms Treatment Outcome
spellingShingle	nintedanib saracatinib small interfering RNA transcription factor ZEB1 uvomorulin antineoplastic agent enzyme inhibitor indole derivative nintedanib animal experiment animal model animal tissue antineoplastic activity Article CD99L2 gene cell proliferation controlled study cytotoxicity down regulation EMP3 gene epithelial mesenchymal transition female gene gene expression gene identification gene silencing human human cell in vitro study in vivo study ITGA5 gene mouse nonhuman ovarian cancer cell line protein expression SYDE1 gene upregulation VIM gene ZEB1 gene animal Bagg albino mouse drug effects epithelial mesenchymal transition genetics metabolism nude mouse Ovarian Neoplasms pathology treatment outcome tumor cell line Animals Antineoplastic Agents Cell Line, Tumor Cell Proliferation Enzyme Inhibitors Epithelial-Mesenchymal Transition Female Humans Indoles Mice Mice, Inbred BALB C Mice, Nude Ovarian Neoplasms Treatment Outcome Huang, R.Y.-J Kuay, K.T Tan, T.Z Asad, M Tang, H.M Chun Ng, A.H Ye, J Chung, V.Y Thiery, J.P Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)
description	10.18632/oncotarget.4300
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Huang, R.Y.-J Kuay, K.T Tan, T.Z Asad, M Tang, H.M Chun Ng, A.H Ye, J Chung, V.Y Thiery, J.P
format	Article
author	Huang, R.Y.-J Kuay, K.T Tan, T.Z Asad, M Tang, H.M Chun Ng, A.H Ye, J Chung, V.Y Thiery, J.P
author_sort	Huang, R.Y.-J
title	Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)
title_short	Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)
title_full	Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)
title_fullStr	Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)
title_full_unstemmed	Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)
title_sort	functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (emt) reversal by the triple angiokinase inhibitor, nintedanib (bibf1120)
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174142
_version_	1821228123105001472

Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)

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