Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)

Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)

10.18632/oncotarget.4300

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Bibliographic Details
Main Authors:	Huang, R.Y.-J, Kuay, K.T, Tan, T.Z, Asad, M, Tang, H.M, Chun Ng, A.H, Ye, J, Chung, V.Y, Thiery, J.P
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	nintedanib saracatinib small interfering RNA transcription factor ZEB1 uvomorulin antineoplastic agent enzyme inhibitor indole derivative animal experiment animal model animal tissue antineoplastic activity Article CD99L2 gene cell proliferation controlled study cytotoxicity down regulation EMP3 gene epithelial mesenchymal transition female gene gene expression gene identification gene silencing human human cell in vitro study in vivo study ITGA5 gene mouse nonhuman ovarian cancer cell line protein expression SYDE1 gene upregulation VIM gene ZEB1 gene animal Bagg albino mouse drug effects genetics metabolism nude mouse Ovarian Neoplasms pathology treatment outcome tumor cell line Animals Antineoplastic Agents Cell Line, Tumor Cell Proliferation Enzyme Inhibitors Epithelial-Mesenchymal Transition Female Humans Indoles Mice Mice, Inbred BALB C Mice, Nude Treatment Outcome
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174142
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Institution:	National University of Singapore

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