p21cip1/waf1 coordinate autophagy, proliferation and apoptosis in response to metabolic stress

by Manu, K.A., Cao, P.H.A., Chai, T.F., Casey, P.J., Wang, M.
Published 2021

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: Potential role as an antiproliferative, pro-apoptotic a...

by Rajendran, P., Li, F., Manu, K.A., Shanmugam, M.K., Loo, S.Y., Kumar, A.P., Sethi, G.
Published 2014

Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products

by Manu, K.A., Shanmugam, M.K., Li, F., Chen, L., Siveen, K.S., Ahn, K.S., Kumar, A.P., Sethi, G.
Published 2014

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB path...

by Manu, K.A., Shanmugam, M.K., Ramachandran, L., Li, F., Fong, C.W., Kumar, A.P., Tan, P., Sethi, G.
Published 2014

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

by Kannaiyan, R., Manu, K.A., Chen, L., Li, F., Rajendran, P., Subramaniam, A., Lam, P., Kumar, A.P., Sethi, G.
Published 2014

Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives

by Sadashiva, M.P., Basappa, Nanjundaswamy, S., Li, F., Manu, K.A., Sengottuvelan, M., Prasanna, D.S., Anilkumar, N.C., Sethi, G., Sugahara, K., Rangappa, K.S.
Published 2014

Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma

by Shanmugam, M.K, Ahn, K.S, Lee, J.H, Kannaiyan, R, Mustafa, N, Manu, K.A, Siveen, K.S, Sethi, G, Chng, W.J, Kumar, A.P
Published 2020

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model

by Shanmugam, M.K., Manu, K.A., Ong, T.H., Ramachandran, L., Surana, R., Bist, P., Lim, L.H.K., Prem Kumar, A., Hui, K.M., Sethi, G.
Published 2014

Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma

by Manu, K.A., Shanmugam, M.K., Ong, T.H., Subramaniam, A., Siveen, K.S., Perumal, E., Samy, R.P., Bist, P., Lim, L.H.K., Kumar, A.P., Hui, K.M., Sethi, G.
Published 2014

An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell surviva...

by Subramaniam, A., Loo, S.Y., Rajendran, P., Manu, K.A., Perumal, E., Li, F., Shanmugam, M.K., Siveen, K.S., Park, J.-I., Ahn, K.S., Hui, K.M., Kumar, A.P., Sethi, G.
Published 2014

Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer

by Ramachandran, L., Manu, K.A., Shanmugam, M.K., Li, F., Siveen, K.S., Vali, S., Kapoor, S., Abbasi, T., Surana, R., Smoot, D.T., Ashktorab, H., Tan, P., Ahn, K.S., Yap, C.W., Kumar, A.P., Sethi, G.
Published 2014

Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

by Manu, K.A., Shanmugam, M.K., Rajendran, P., Li, F., Ramachandran, L., Hay, H.S., Kannaiyan, R., Swamy, S.N., Vali, S., Kapoor, S., Ramesh, B., Bist, P., Koay, E.S., Lim, L.H.K., Ahn, K.S., Kumar, A.P., Sethi, G.
Published 2014