A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

10.1038/s41467-018-03441-3

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Bibliographic Details
Main Authors:	Ladds, M.J.G.W, Van Leeuwen, I.M.M, Drummond, C.J
Other Authors:	MEDICINE
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	antineoplastic agent dihydroorotate dehydrogenase dihydroorotate dehydrogenase inhibitor hz 00 hz 05 nutlin 3 protein p53 unclassified drug enzyme inhibitor indazole derivative oxidoreductase biodegradation cancer cell chemical compound crystal structure enzyme enzyme activity growth inhibitor protein tumor animal cell animal experiment animal model antineoplastic activity Article cancer cell cancer combination chemotherapy cell cycle S phase cell killing chirality controlled study drug identification drug mechanism enantiomer enzyme inhibition human human cell in vivo study malignant neoplasm melanoma mouse nonhuman protein degradation protein denaturation protein synthesis tumor growth antagonists and inhibitors cell cycle cell proliferation chemistry drug effect enzymology genetics metabolism neoplasm tumor cell line Antineoplastic Agents Cell Cycle Cell Line, Tumor Cell Proliferation Enzyme Inhibitors Humans Indazoles Neoplasms Oxidoreductases Acting on CH-CH Group Donors Proteolysis Tumor Suppressor Protein p53
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178423
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Institution:	National University of Singapore

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