A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

• Main Authors: Ladds, M.J.G.W, Van Leeuwen, I.M.M, Drummond, C.J
• Other Authors: MEDICINE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: antineoplastic agent; dihydroorotate dehydrogenase; dihydroorotate dehydrogenase inhibitor; hz 00; hz 05; nutlin 3; protein p53; unclassified drug; enzyme inhibitor; indazole derivative; oxidoreductase; biodegradation; cancer; cell; chemical compound; crystal structure; enzyme; enzyme activity; growth; inhibitor; protein; tumor; animal cell; animal experiment; animal model; antineoplastic activity; Article; cancer cell; cancer combination chemotherapy; cell cycle S phase; cell killing; chirality; controlled study; drug identification; drug mechanism; enantiomer; enzyme inhibition; human; human cell; in vivo study; malignant neoplasm; melanoma; mouse; nonhuman; protein degradation; protein denaturation; protein synthesis; tumor growth; antagonists and inhibitors; cell cycle; cell proliferation; chemistry; drug effect; enzymology; genetics; metabolism; neoplasm; tumor cell line; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Humans; Indazoles; Neoplasms; Oxidoreductases Acting on CH-CH Group Donors; Proteolysis; Tumor Suppressor Protein p53
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178423
• Institution: National University of Singapore

10.1038/s41467-018-03441-3