A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

10.1038/s41467-018-03441-3

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Main Authors:	Ladds, M.J.G.W, Van Leeuwen, I.M.M, Drummond, C.J
Other Authors:	MEDICINE
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	antineoplastic agent dihydroorotate dehydrogenase dihydroorotate dehydrogenase inhibitor hz 00 hz 05 nutlin 3 protein p53 unclassified drug enzyme inhibitor indazole derivative oxidoreductase biodegradation cancer cell chemical compound crystal structure enzyme enzyme activity growth inhibitor protein tumor animal cell animal experiment animal model antineoplastic activity Article cancer cell cancer combination chemotherapy cell cycle S phase cell killing chirality controlled study drug identification drug mechanism enantiomer enzyme inhibition human human cell in vivo study malignant neoplasm melanoma mouse nonhuman protein degradation protein denaturation protein synthesis tumor growth antagonists and inhibitors cell cycle cell proliferation chemistry drug effect enzymology genetics metabolism neoplasm tumor cell line Antineoplastic Agents Cell Cycle Cell Line, Tumor Cell Proliferation Enzyme Inhibitors Humans Indazoles Neoplasms Oxidoreductases Acting on CH-CH Group Donors Proteolysis Tumor Suppressor Protein p53
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178423
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1784232024-05-08T09:51:10Z A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage Ladds, M.J.G.W Van Leeuwen, I.M.M Drummond, C.J MEDICINE antineoplastic agent dihydroorotate dehydrogenase dihydroorotate dehydrogenase inhibitor hz 00 hz 05 nutlin 3 protein p53 unclassified drug antineoplastic agent enzyme inhibitor indazole derivative oxidoreductase protein p53 biodegradation cancer cell chemical compound crystal structure enzyme enzyme activity growth inhibitor protein tumor animal cell animal experiment animal model antineoplastic activity Article cancer cell cancer combination chemotherapy cell cycle S phase cell killing chirality controlled study crystal structure drug identification drug mechanism enantiomer enzyme inhibition human human cell in vivo study malignant neoplasm melanoma mouse nonhuman protein degradation protein denaturation protein synthesis tumor growth antagonists and inhibitors cell cycle cell proliferation chemistry drug effect enzymology genetics metabolism neoplasm protein degradation tumor cell line Antineoplastic Agents Cell Cycle Cell Line, Tumor Cell Proliferation Enzyme Inhibitors Humans Indazoles Neoplasms Oxidoreductases Acting on CH-CH Group Donors Proteolysis Tumor Suppressor Protein p53 10.1038/s41467-018-03441-3 Nature Communications 9 1 1107 2020-10-20T09:53:37Z 2020-10-20T09:53:37Z 2018 Article Ladds, M.J.G.W, Van Leeuwen, I.M.M, Drummond, C.J (2018). A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage. Nature Communications 9 (1) : 1107. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-03441-3 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/178423 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antineoplastic agent dihydroorotate dehydrogenase dihydroorotate dehydrogenase inhibitor hz 00 hz 05 nutlin 3 protein p53 unclassified drug antineoplastic agent enzyme inhibitor indazole derivative oxidoreductase protein p53 biodegradation cancer cell chemical compound crystal structure enzyme enzyme activity growth inhibitor protein tumor animal cell animal experiment animal model antineoplastic activity Article cancer cell cancer combination chemotherapy cell cycle S phase cell killing chirality controlled study crystal structure drug identification drug mechanism enantiomer enzyme inhibition human human cell in vivo study malignant neoplasm melanoma mouse nonhuman protein degradation protein denaturation protein synthesis tumor growth antagonists and inhibitors cell cycle cell proliferation chemistry drug effect enzymology genetics metabolism neoplasm protein degradation tumor cell line Antineoplastic Agents Cell Cycle Cell Line, Tumor Cell Proliferation Enzyme Inhibitors Humans Indazoles Neoplasms Oxidoreductases Acting on CH-CH Group Donors Proteolysis Tumor Suppressor Protein p53
spellingShingle	antineoplastic agent dihydroorotate dehydrogenase dihydroorotate dehydrogenase inhibitor hz 00 hz 05 nutlin 3 protein p53 unclassified drug antineoplastic agent enzyme inhibitor indazole derivative oxidoreductase protein p53 biodegradation cancer cell chemical compound crystal structure enzyme enzyme activity growth inhibitor protein tumor animal cell animal experiment animal model antineoplastic activity Article cancer cell cancer combination chemotherapy cell cycle S phase cell killing chirality controlled study crystal structure drug identification drug mechanism enantiomer enzyme inhibition human human cell in vivo study malignant neoplasm melanoma mouse nonhuman protein degradation protein denaturation protein synthesis tumor growth antagonists and inhibitors cell cycle cell proliferation chemistry drug effect enzymology genetics metabolism neoplasm protein degradation tumor cell line Antineoplastic Agents Cell Cycle Cell Line, Tumor Cell Proliferation Enzyme Inhibitors Humans Indazoles Neoplasms Oxidoreductases Acting on CH-CH Group Donors Proteolysis Tumor Suppressor Protein p53 Ladds, M.J.G.W Van Leeuwen, I.M.M Drummond, C.J A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
description	10.1038/s41467-018-03441-3
author2	MEDICINE
author_facet	MEDICINE Ladds, M.J.G.W Van Leeuwen, I.M.M Drummond, C.J
format	Article
author	Ladds, M.J.G.W Van Leeuwen, I.M.M Drummond, C.J
author_sort	Ladds, M.J.G.W
title	A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
title_short	A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
title_full	A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
title_fullStr	A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
title_full_unstemmed	A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
title_sort	dhodh inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178423
_version_	1800914498562818048

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

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