Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma

10.3389/fphar.2018.00365

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Main Authors:	Shanmugam, M.K, Ahn, K.S, Lee, J.H, Kannaiyan, R, Mustafa, N, Manu, K.A, Siveen, K.S, Sethi, G, Chng, W.J, Kumar, A.P
Other Authors:	PHARMACOLOGY
Format:	Article
Published:	2020
Subjects:	bortezomib caspase 3 celastrol chemokine receptor CXCR4 gelatinase B immunoglobulin enhancer binding protein interleukin 6 syndecan 1 tumor necrosis factor animal cell animal experiment animal model animal tissue antineoplastic activity apoptosis Article cell invasion cell migration cell proliferation controlled study CXCR4 gene drug effect drug structure enzyme activation enzyme repression gene product human human cell human tissue in vitro study in vivo study male MMP 9 gene mouse multiple myeloma nonhuman protein blood level protein expression tumor growth tumor xenograft upregulation
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175386
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1753862024-04-24T05:54:40Z Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma Shanmugam, M.K Ahn, K.S Lee, J.H Kannaiyan, R Mustafa, N Manu, K.A Siveen, K.S Sethi, G Chng, W.J Kumar, A.P PHARMACOLOGY MEDICINE DUKE-NUS MEDICAL SCHOOL CANCER SCIENCE INSTITUTE OF SINGAPORE bortezomib caspase 3 celastrol chemokine receptor CXCR4 gelatinase B immunoglobulin enhancer binding protein interleukin 6 syndecan 1 tumor necrosis factor animal cell animal experiment animal model animal tissue antineoplastic activity apoptosis Article cell invasion cell migration cell proliferation controlled study CXCR4 gene drug effect drug structure enzyme activation enzyme repression gene product human human cell human tissue in vitro study in vivo study male MMP 9 gene mouse multiple myeloma nonhuman protein blood level protein expression tumor growth tumor xenograft upregulation 10.3389/fphar.2018.00365 Frontiers in Pharmacology 9 MAY 365 2020-09-09T10:07:27Z 2020-09-09T10:07:27Z 2018 Article Shanmugam, M.K, Ahn, K.S, Lee, J.H, Kannaiyan, R, Mustafa, N, Manu, K.A, Siveen, K.S, Sethi, G, Chng, W.J, Kumar, A.P (2018). Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma. Frontiers in Pharmacology 9 (MAY) : 365. ScholarBank@NUS Repository. https://doi.org/10.3389/fphar.2018.00365 1663-9812 https://scholarbank.nus.edu.sg/handle/10635/175386 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	bortezomib caspase 3 celastrol chemokine receptor CXCR4 gelatinase B immunoglobulin enhancer binding protein interleukin 6 syndecan 1 tumor necrosis factor animal cell animal experiment animal model animal tissue antineoplastic activity apoptosis Article cell invasion cell migration cell proliferation controlled study CXCR4 gene drug effect drug structure enzyme activation enzyme repression gene product human human cell human tissue in vitro study in vivo study male MMP 9 gene mouse multiple myeloma nonhuman protein blood level protein expression tumor growth tumor xenograft upregulation
spellingShingle	bortezomib caspase 3 celastrol chemokine receptor CXCR4 gelatinase B immunoglobulin enhancer binding protein interleukin 6 syndecan 1 tumor necrosis factor animal cell animal experiment animal model animal tissue antineoplastic activity apoptosis Article cell invasion cell migration cell proliferation controlled study CXCR4 gene drug effect drug structure enzyme activation enzyme repression gene product human human cell human tissue in vitro study in vivo study male MMP 9 gene mouse multiple myeloma nonhuman protein blood level protein expression tumor growth tumor xenograft upregulation Shanmugam, M.K Ahn, K.S Lee, J.H Kannaiyan, R Mustafa, N Manu, K.A Siveen, K.S Sethi, G Chng, W.J Kumar, A.P Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
description	10.3389/fphar.2018.00365
author2	PHARMACOLOGY
author_facet	PHARMACOLOGY Shanmugam, M.K Ahn, K.S Lee, J.H Kannaiyan, R Mustafa, N Manu, K.A Siveen, K.S Sethi, G Chng, W.J Kumar, A.P
format	Article
author	Shanmugam, M.K Ahn, K.S Lee, J.H Kannaiyan, R Mustafa, N Manu, K.A Siveen, K.S Sethi, G Chng, W.J Kumar, A.P
author_sort	Shanmugam, M.K
title	Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
title_short	Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
title_full	Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
title_fullStr	Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
title_full_unstemmed	Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
title_sort	celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175386
_version_	1800914361154273280

Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma

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