RNAi screen reveals a role of SPHK2 in dengue virus–mediated apoptosis in hepatic cell lines

• Main Authors: Morchang A., Lee R.C.H., Yenchitsomanus P.-T., Sreekanth G.P., Noisakran S., Chu J.J.H., Limjindaporn T.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2019
• Subjects: abc 294649; caspase 3; caspase 8; caspase 9; phosphotransferase inhibitor; small interfering RNA; sphingosine kinase 2; tumor necrosis factor; tumor necrosis factor superfamily member 12; unclassified drug; phosphotransferase; sphingosine kinase 2, human; apoptosis; Article; Dengue virus; enzyme activity; gene function; gene silencing; genetic screening; Hep-G2 cell line; Huh-7 cell line; human; human cell; liver cell; RNA interference; SPHK2 gene; TNFSF12 gene; cell line; genetics; liver; metabolism; physiology; real time polymerase chain reaction; virology; virus replication; Apoptosis; Caspase 3; Cell Line; Dengue Virus; Gene Knockdown Techniques; Humans; Liver; Phosphotransferases (Alcohol Group Acceptor); Real-Time Polymerase Chain Reaction; RNA Interference; Virus Replication
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161167
• Institution: National University of Singapore

10.1371/journal.pone.0188121