Dengue 2 infection of HepG2 liver cells results in endoplasmic reticulum stress and induction of multiple pathways of cell death

• Main Authors: Chutima Thepparit, Khakpoor, Atefeh, Sarawut Khongwichit, Nitwara Wikan, Chanida Fongsaran, Pimjai Chingsuwanrote, Patcharee Panraksa, Smith, Duncan R
• Other Authors: Mahidol University. Institute of Molecular Biosciences. Molecular Pathology Laboratory
• Format: Article
• Language: English
• Published: 2015
• Subjects: Apoptosis; Autophagy; Caspase; Dengue; ER stress liver; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/1815
• Institution: Mahidol University

Background A number of studies have implicated the direct involvement of the liver in dengue virus (DENV) infection, and it has been widely shown that liver cells subsequently undergo apoptosis. The mechanism by which liver cells undergo apoptosis in response to DENV infection remains unclear. To p...