Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation

10.1371/journal.pone.0182707

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Main Authors:	Modi H.R., Wang Q., Sahithi G.D., Sherman D., Greenwald E., Savonenko A.V., Geocadin R.G., Thakor N.V.
Other Authors:	BIOMEDICAL ENGINEERING
Format:	Article
Published:	2019
Subjects:	CD11b antigen glial fibrillary acidic protein inducible nitric oxide synthase interleukin 1beta orexin 1 receptor orexin 2 receptor orexin A tumor necrosis factor biological marker messenger RNA orexin orexin receptor sodium chloride adult animal experiment animal model animal tissue antiinflammatory activity arousal Article behavior assessment coma controlled study electroencephalography heart arrest hippocampus hypothalamus induced hypothermia male nervous system inflammation Neurologic Deficit Scale score neurologic examination neuroprotection nonhuman outcome assessment prefrontal cortex protein localization rat real time polymerase chain reaction return of spontaneous circulation treatment outcome treatment response animal animal behavior brain complication drug effects gamma rhythm genetics hemodynamics inflammation intranasal drug administration metabolism pathology pathophysiology resuscitation Wistar rat Administration, Intranasal Animals Arousal Behavior, Animal Biomarkers Brain Coma Electroencephalography Gamma Rhythm Heart Arrest Hemodynamics Inflammation Male Orexin Receptors Orexins Rats, Wistar Resuscitation RNA, Messenger Sodium Chloride Treatment Outcome
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161174
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1611742024-04-25T03:37:40Z Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation Modi H.R. Wang Q. Sahithi G.D. Sherman D. Greenwald E. Savonenko A.V. Geocadin R.G. Thakor N.V. BIOMEDICAL ENGINEERING ELECTRICAL AND COMPUTER ENGINEERING CD11b antigen glial fibrillary acidic protein inducible nitric oxide synthase interleukin 1beta orexin 1 receptor orexin 2 receptor orexin A tumor necrosis factor biological marker messenger RNA orexin orexin receptor sodium chloride adult animal experiment animal model animal tissue antiinflammatory activity arousal Article behavior assessment coma controlled study electroencephalography heart arrest hippocampus hypothalamus induced hypothermia male nervous system inflammation Neurologic Deficit Scale score neurologic examination neuroprotection nonhuman outcome assessment prefrontal cortex protein localization rat real time polymerase chain reaction return of spontaneous circulation treatment outcome treatment response animal animal behavior brain coma complication drug effects gamma rhythm genetics heart arrest hemodynamics inflammation intranasal drug administration metabolism pathology pathophysiology resuscitation Wistar rat Administration, Intranasal Animals Arousal Behavior, Animal Biomarkers Brain Coma Electroencephalography Gamma Rhythm Heart Arrest Hemodynamics Inflammation Male Orexin Receptors Orexins Rats, Wistar Resuscitation RNA, Messenger Sodium Chloride Treatment Outcome 10.1371/journal.pone.0182707 PLoS ONE 12 9 e0182707 2019-11-01T07:48:50Z 2019-11-01T07:48:50Z 2017 Article Modi H.R., Wang Q., Sahithi G.D., Sherman D., Greenwald E., Savonenko A.V., Geocadin R.G., Thakor N.V. (2017). Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation. PLoS ONE 12 (9) : e0182707. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0182707 19326203 https://scholarbank.nus.edu.sg/handle/10635/161174 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	CD11b antigen glial fibrillary acidic protein inducible nitric oxide synthase interleukin 1beta orexin 1 receptor orexin 2 receptor orexin A tumor necrosis factor biological marker messenger RNA orexin orexin receptor sodium chloride adult animal experiment animal model animal tissue antiinflammatory activity arousal Article behavior assessment coma controlled study electroencephalography heart arrest hippocampus hypothalamus induced hypothermia male nervous system inflammation Neurologic Deficit Scale score neurologic examination neuroprotection nonhuman outcome assessment prefrontal cortex protein localization rat real time polymerase chain reaction return of spontaneous circulation treatment outcome treatment response animal animal behavior brain coma complication drug effects gamma rhythm genetics heart arrest hemodynamics inflammation intranasal drug administration metabolism pathology pathophysiology resuscitation Wistar rat Administration, Intranasal Animals Arousal Behavior, Animal Biomarkers Brain Coma Electroencephalography Gamma Rhythm Heart Arrest Hemodynamics Inflammation Male Orexin Receptors Orexins Rats, Wistar Resuscitation RNA, Messenger Sodium Chloride Treatment Outcome
spellingShingle	CD11b antigen glial fibrillary acidic protein inducible nitric oxide synthase interleukin 1beta orexin 1 receptor orexin 2 receptor orexin A tumor necrosis factor biological marker messenger RNA orexin orexin receptor sodium chloride adult animal experiment animal model animal tissue antiinflammatory activity arousal Article behavior assessment coma controlled study electroencephalography heart arrest hippocampus hypothalamus induced hypothermia male nervous system inflammation Neurologic Deficit Scale score neurologic examination neuroprotection nonhuman outcome assessment prefrontal cortex protein localization rat real time polymerase chain reaction return of spontaneous circulation treatment outcome treatment response animal animal behavior brain coma complication drug effects gamma rhythm genetics heart arrest hemodynamics inflammation intranasal drug administration metabolism pathology pathophysiology resuscitation Wistar rat Administration, Intranasal Animals Arousal Behavior, Animal Biomarkers Brain Coma Electroencephalography Gamma Rhythm Heart Arrest Hemodynamics Inflammation Male Orexin Receptors Orexins Rats, Wistar Resuscitation RNA, Messenger Sodium Chloride Treatment Outcome Modi H.R. Wang Q. Sahithi G.D. Sherman D. Greenwald E. Savonenko A.V. Geocadin R.G. Thakor N.V. Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation
description	10.1371/journal.pone.0182707
author2	BIOMEDICAL ENGINEERING
author_facet	BIOMEDICAL ENGINEERING Modi H.R. Wang Q. Sahithi G.D. Sherman D. Greenwald E. Savonenko A.V. Geocadin R.G. Thakor N.V.
format	Article
author	Modi H.R. Wang Q. Sahithi G.D. Sherman D. Greenwald E. Savonenko A.V. Geocadin R.G. Thakor N.V.
author_sort	Modi H.R.
title	Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation
title_short	Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation
title_full	Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation
title_fullStr	Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation
title_full_unstemmed	Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation
title_sort	intranasal post-cardiac arrest treatment with orexin-a facilitates arousal from coma and ameliorates neuroinflammation
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161174
_version_	1800913781273919488

Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation

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