Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation

• Main Authors: Modi H.R., Wang Q., Sahithi G.D., Sherman D., Greenwald E., Savonenko A.V., Geocadin R.G., Thakor N.V.
• Other Authors: BIOMEDICAL ENGINEERING
• Format: Article
• Published: 2019
• Subjects: CD11b antigen; glial fibrillary acidic protein; inducible nitric oxide synthase; interleukin 1beta; orexin 1 receptor; orexin 2 receptor; orexin A; tumor necrosis factor; biological marker; messenger RNA; orexin; orexin receptor; sodium chloride; adult; animal experiment; animal model; animal tissue; antiinflammatory activity; arousal; Article; behavior assessment; coma; controlled study; electroencephalography; heart arrest; hippocampus; hypothalamus; induced hypothermia; male; nervous system inflammation; Neurologic Deficit Scale score; neurologic examination; neuroprotection; nonhuman; outcome assessment; prefrontal cortex; protein localization; rat; real time polymerase chain reaction; return of spontaneous circulation; treatment outcome; treatment response; animal; animal behavior; brain; complication; drug effects; gamma rhythm; genetics; hemodynamics; inflammation; intranasal drug administration; metabolism; pathology; pathophysiology; resuscitation; Wistar rat; Administration, Intranasal; Animals; Arousal; Behavior, Animal; Biomarkers; Brain; Coma; Electroencephalography; Gamma Rhythm; Heart Arrest; Hemodynamics; Inflammation; Male; Orexin Receptors; Orexins; Rats, Wistar; Resuscitation; RNA, Messenger; Sodium Chloride; Treatment Outcome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161174
• Institution: National University of Singapore

10.1371/journal.pone.0182707