Astrocyte-derived proinflammatory cytokines induce hypomyelination in the periventricular white matter in the hypoxic neonatal brain

• Main Authors: Deng Y., Xie D., Fang M., Zhu G., Chen C., Zeng H., Lu J., Charanjit K.
• Other Authors: ANATOMY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: interleukin 1 receptor type I; interleukin 1beta; tumor necrosis factor alpha; tumor necrosis factor receptor 1; animal cell; animal experiment; animal model; animal tissue; antigen presenting cell; apoptosis; article; astrocyte; brain hypoxia; cell culture; controlled study; demyelination; electron microscopy; female; hypomyelination; immunofluorescence; immunopathogenesis; myelination; nerve fiber; nonhuman; oligodendroglia; periventricular white matter disorder; protein expression; real time polymerase chain reaction; upregulation; Western blotting; white matter lesion; Wistar rat; Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Demyelinating Diseases; Hypoxia, Brain; Inflammation Mediators; Interleukin-1beta; Myelin Sheath; Oligodendroglia; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Up-Regulation
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165961
• Institution: National University of Singapore

10.1371/journal.pone.0087420