Efficacy and tolerability of rivastigmine patch therapy in patients with mild-to-moderate Alzheimer’s dementia associated with minimal and moderate ischemic white matter hyperintensities: A multicenter prospective open-label clinical trial

• Main Authors: Park K.W., Kim E.-J., Han H.J., Shim Y.S., Kwon J.C., Ku B.D., Park K.H., Yi H.-A., Kim K.K., Yang D.W., Lee H.-W., Kang H., Kwon O.D., Kim S., Lee J.-H., Chung E.J., Park S.-W., Park M.Y., Yoon B., Kim B.C., Seo S.W., Choi S.H.
• Other Authors: BIOLOGY
• Format: Article
• Published: 2019
• Subjects: rivastigmine; cholinesterase inhibitor; neuroprotective agent; abscess; aged; Alzheimer disease; Alzheimer Disease Assessment Scale; anorexia; Article; bradycardia; clinical trial; dizziness; drug dose titration; drug efficacy; drug tolerability; drug withdrawal; dyspnea; edema; epigastric discomfort; epigastric pain; female; fracture; headache; herpes zoster; human; intention to treat analysis; major clinical study; male; multicenter study; nausea; nervous system parameters; open study; paresthesia; prospective study; pruritus; rash; shoulder pain; skin irritation; treatment outcome; upper respiratory tract infection; vomiting; white matter; white matter hyperintensity; brain; diagnostic imaging; drug effects; middle aged; severity of illness index; South Korea; transdermal patch; very elderly; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cholinesterase Inhibitors; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Republic of Korea; Rivastigmine; Severity of Illness Index; Transdermal Patch; Treatment Outcome; White Matter
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161180
• Institution: National University of Singapore

10.1371/journal.pone.0182123