Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients

10.1371/journal.pone.0173772

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Main Authors:	Thean L.F., Wong Y.H., Lo M., Loi C., Chew M.H., Tang C.L., Cheah P.Y.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	long untranslated RNA MIA protein microRNA 24 oncoprotein PIM2 protein RAB4B protein TAOK1 protein unclassified drug CYP2A7 protein, human cytochrome P450 family 2 EGLN2 protein, human hypoxia inducible factor proline dioxygenase MIA protein, human scleroprotein tumor protein unspecific monooxygenase 3' untranslated region adenomatous polyposis coli gene adult Article binding site case report chromosome 19q chromosome 19q13 colorectal cancer controlled study CYP2A7 gene familial colon polyposis gene gene deletion gene dosage gene expression gene location gene mutation gene targeting genetic association heterozygosity human male real time polymerase chain reaction reverse transcription polymerase chain reaction upregulation young adult chromosome 19 colon polyposis colorectal tumor female genetics pedigree tumor suppressor gene Adenomatous Polyposis Coli Aryl Hydrocarbon Hydroxylases Chromosomes, Human, Pair 19 Colorectal Neoplasms Cytochrome P450 Family 2 Extracellular Matrix Proteins Female Genes, APC Humans Hypoxia-Inducible Factor-Proline Dioxygenases Male Neoplasm Proteins Pedigree RNA, Long Noncoding
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161204
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1612042020-11-18T01:51:22Z Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients Thean L.F. Wong Y.H. Lo M. Loi C. Chew M.H. Tang C.L. Cheah P.Y. DUKE-NUS MEDICAL SCHOOL long untranslated RNA MIA protein microRNA 24 oncoprotein PIM2 protein RAB4B protein TAOK1 protein unclassified drug CYP2A7 protein, human cytochrome P450 family 2 EGLN2 protein, human hypoxia inducible factor proline dioxygenase long untranslated RNA MIA protein, human scleroprotein tumor protein unspecific monooxygenase 3' untranslated region adenomatous polyposis coli gene adult Article binding site case report chromosome 19q chromosome 19q13 colorectal cancer controlled study CYP2A7 gene familial colon polyposis gene gene deletion gene dosage gene expression gene location gene mutation gene targeting genetic association heterozygosity human male real time polymerase chain reaction reverse transcription polymerase chain reaction upregulation young adult chromosome 19 colon polyposis colorectal tumor female genetics pedigree tumor suppressor gene Adenomatous Polyposis Coli Aryl Hydrocarbon Hydroxylases Chromosomes, Human, Pair 19 Colorectal Neoplasms Cytochrome P450 Family 2 Extracellular Matrix Proteins Female Genes, APC Humans Hypoxia-Inducible Factor-Proline Dioxygenases Male Neoplasm Proteins Pedigree RNA, Long Noncoding 10.1371/journal.pone.0173772 PLoS ONE 12 3 e0173772 2019-11-01T07:55:01Z 2019-11-01T07:55:01Z 2017 Article Thean L.F., Wong Y.H., Lo M., Loi C., Chew M.H., Tang C.L., Cheah P.Y. (2017). Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients. PLoS ONE 12 (3) : e0173772. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0173772 19326203 https://scholarbank.nus.edu.sg/handle/10635/161204 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	long untranslated RNA MIA protein microRNA 24 oncoprotein PIM2 protein RAB4B protein TAOK1 protein unclassified drug CYP2A7 protein, human cytochrome P450 family 2 EGLN2 protein, human hypoxia inducible factor proline dioxygenase long untranslated RNA MIA protein, human scleroprotein tumor protein unspecific monooxygenase 3' untranslated region adenomatous polyposis coli gene adult Article binding site case report chromosome 19q chromosome 19q13 colorectal cancer controlled study CYP2A7 gene familial colon polyposis gene gene deletion gene dosage gene expression gene location gene mutation gene targeting genetic association heterozygosity human male real time polymerase chain reaction reverse transcription polymerase chain reaction upregulation young adult chromosome 19 colon polyposis colorectal tumor female genetics pedigree tumor suppressor gene Adenomatous Polyposis Coli Aryl Hydrocarbon Hydroxylases Chromosomes, Human, Pair 19 Colorectal Neoplasms Cytochrome P450 Family 2 Extracellular Matrix Proteins Female Genes, APC Humans Hypoxia-Inducible Factor-Proline Dioxygenases Male Neoplasm Proteins Pedigree RNA, Long Noncoding
spellingShingle	long untranslated RNA MIA protein microRNA 24 oncoprotein PIM2 protein RAB4B protein TAOK1 protein unclassified drug CYP2A7 protein, human cytochrome P450 family 2 EGLN2 protein, human hypoxia inducible factor proline dioxygenase long untranslated RNA MIA protein, human scleroprotein tumor protein unspecific monooxygenase 3' untranslated region adenomatous polyposis coli gene adult Article binding site case report chromosome 19q chromosome 19q13 colorectal cancer controlled study CYP2A7 gene familial colon polyposis gene gene deletion gene dosage gene expression gene location gene mutation gene targeting genetic association heterozygosity human male real time polymerase chain reaction reverse transcription polymerase chain reaction upregulation young adult chromosome 19 colon polyposis colorectal tumor female genetics pedigree tumor suppressor gene Adenomatous Polyposis Coli Aryl Hydrocarbon Hydroxylases Chromosomes, Human, Pair 19 Colorectal Neoplasms Cytochrome P450 Family 2 Extracellular Matrix Proteins Female Genes, APC Humans Hypoxia-Inducible Factor-Proline Dioxygenases Male Neoplasm Proteins Pedigree RNA, Long Noncoding Thean L.F. Wong Y.H. Lo M. Loi C. Chew M.H. Tang C.L. Cheah P.Y. Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients
description	10.1371/journal.pone.0173772
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Thean L.F. Wong Y.H. Lo M. Loi C. Chew M.H. Tang C.L. Cheah P.Y.
format	Article
author	Thean L.F. Wong Y.H. Lo M. Loi C. Chew M.H. Tang C.L. Cheah P.Y.
author_sort	Thean L.F.
title	Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients
title_short	Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients
title_full	Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients
title_fullStr	Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients
title_full_unstemmed	Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients
title_sort	chromosome 19q13 disruption alters expressions of cyp2a7, mia and mia-rab4b lncrna and contributes to fap-like phenotype in apc mutation-negative familial colorectal cancer patients
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161204
_version_	1686108435947454464

Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients

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