Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients

• Main Authors: Thean L.F., Wong Y.H., Lo M., Loi C., Chew M.H., Tang C.L., Cheah P.Y.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: long untranslated RNA; MIA protein; microRNA 24; oncoprotein; PIM2 protein; RAB4B protein; TAOK1 protein; unclassified drug; CYP2A7 protein, human; cytochrome P450 family 2; EGLN2 protein, human; hypoxia inducible factor proline dioxygenase; MIA protein, human; scleroprotein; tumor protein; unspecific monooxygenase; 3' untranslated region; adenomatous polyposis coli gene; adult; Article; binding site; case report; chromosome 19q; chromosome 19q13; colorectal cancer; controlled study; CYP2A7 gene; familial colon polyposis; gene; gene deletion; gene dosage; gene expression; gene location; gene mutation; gene targeting; genetic association; heterozygosity; human; male; real time polymerase chain reaction; reverse transcription polymerase chain reaction; upregulation; young adult; chromosome 19; colon polyposis; colorectal tumor; female; genetics; pedigree; tumor suppressor gene; Adenomatous Polyposis Coli; Aryl Hydrocarbon Hydroxylases; Chromosomes, Human, Pair 19; Colorectal Neoplasms; Cytochrome P450 Family 2; Extracellular Matrix Proteins; Female; Genes, APC; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; Male; Neoplasm Proteins; Pedigree; RNA, Long Noncoding
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161204
• Institution: National University of Singapore

10.1371/journal.pone.0173772