Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma

• Main Authors: Wiggs J.L., Yaspan B.L., Hauser M.A., Kang J.H., Allingham R.R., Olson L.M., Abdrabou W., Fan B.J., Wang D.Y., Brodeur W., Budenz D.L., Caprioli J., Crenshaw A., Crooks K., DelBono E., Doheny K.F., Friedman D.S., Gaasterland D., Gaasterland T., Laurie C., Lee R.K., Lichter P.R., Loomis S., Liu Y., Medeiros F.A., McCarty C., Mirel D., Moroi S.E., Musch D.C., Realini A., Rozsa F.W., Schuman J.S., Scott K., Singh K., Stein J.D., Trager E.H., VanVeldhuisen P., Vollrath D., Wollstein G., Yoneyama S., Zhang K., Weinreb R.N., Ernst J., Kellis M., Masuda T., Zack D., Richards J.E., Pericak-Vance M., Pasquale L.R., Haines J.L.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: animal experiment; animal model; animal tissue; article; CDKN2BAS gene; chromosome 14q; chromosome 8q; chromosome 9p; controlled study; disease association; disease classification; DNA sequence; exfoliation syndrome; gene; gene expression profiling; gene function; gene location; gene locus; genetic association; genetic identification; genetic susceptibility; genetic variability; human; intraocular pressure; LRP12 gene; major clinical study; mouse; nerve degeneration; nonhuman; open angle glaucoma; optic nerve disease; signal transduction; single nucleotide polymorphism; ZFPM2 gene; allele; chromosome 8; chromosome 9; genetics; meta analysis; metabolism; optic nerve; pathology; ANRIL long non coding RNA, human; ANRIL long non-coding RNA, human; homeodomain protein; SIX1 protein, human; transforming growth factor beta; untranslated RNA; Alleles; Chromosomes, Human, Pair 8; Chromosomes, Human, Pair 9; Exfoliation Syndrome; Genome-Wide Association Study; Glaucoma, Open-Angle; Homeodomain Proteins; Humans; Nerve Degeneration; Optic Nerve; Polymorphism, Single Nucleotide; RNA, Untranslated; Transforming Growth Factor beta
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161641
• Institution: National University of Singapore

10.1371/journal.pgen.1002654