Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma

10.1371/journal.pgen.1002654

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Main Authors:	Wiggs J.L., Yaspan B.L., Hauser M.A., Kang J.H., Allingham R.R., Olson L.M., Abdrabou W., Fan B.J., Wang D.Y., Brodeur W., Budenz D.L., Caprioli J., Crenshaw A., Crooks K., DelBono E., Doheny K.F., Friedman D.S., Gaasterland D., Gaasterland T., Laurie C., Lee R.K., Lichter P.R., Loomis S., Liu Y., Medeiros F.A., McCarty C., Mirel D., Moroi S.E., Musch D.C., Realini A., Rozsa F.W., Schuman J.S., Scott K., Singh K., Stein J.D., Trager E.H., VanVeldhuisen P., Vollrath D., Wollstein G., Yoneyama S., Zhang K., Weinreb R.N., Ernst J., Kellis M., Masuda T., Zack D., Richards J.E., Pericak-Vance M., Pasquale L.R., Haines J.L.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	animal experiment animal model animal tissue article CDKN2BAS gene chromosome 14q chromosome 8q chromosome 9p controlled study disease association disease classification DNA sequence exfoliation syndrome gene gene expression profiling gene function gene location gene locus genetic association genetic identification genetic susceptibility genetic variability human intraocular pressure LRP12 gene major clinical study mouse nerve degeneration nonhuman open angle glaucoma optic nerve disease signal transduction single nucleotide polymorphism ZFPM2 gene allele chromosome 8 chromosome 9 genetics meta analysis metabolism optic nerve pathology ANRIL long non coding RNA, human ANRIL long non-coding RNA, human homeodomain protein SIX1 protein, human transforming growth factor beta untranslated RNA Alleles Chromosomes, Human, Pair 8 Chromosomes, Human, Pair 9 Exfoliation Syndrome Genome-Wide Association Study Glaucoma, Open-Angle Homeodomain Proteins Humans Nerve Degeneration Optic Nerve Polymorphism, Single Nucleotide RNA, Untranslated Transforming Growth Factor beta
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161641
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spelling	sg-nus-scholar.10635-1616412023-10-31T08:36:23Z Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma Wiggs J.L. Yaspan B.L. Hauser M.A. Kang J.H. Allingham R.R. Olson L.M. Abdrabou W. Fan B.J. Wang D.Y. Brodeur W. Budenz D.L. Caprioli J. Crenshaw A. Crooks K. DelBono E. Doheny K.F. Friedman D.S. Gaasterland D. Gaasterland T. Laurie C. Lee R.K. Lichter P.R. Loomis S. Liu Y. Medeiros F.A. McCarty C. Mirel D. Moroi S.E. Musch D.C. Realini A. Rozsa F.W. Schuman J.S. Scott K. Singh K. Stein J.D. Trager E.H. VanVeldhuisen P. Vollrath D. Wollstein G. Yoneyama S. Zhang K. Weinreb R.N. Ernst J. Kellis M. Masuda T. Zack D. Richards J.E. Pericak-Vance M. Pasquale L.R. Haines J.L. DUKE-NUS MEDICAL SCHOOL animal experiment animal model animal tissue article CDKN2BAS gene chromosome 14q chromosome 8q chromosome 9p controlled study disease association disease classification DNA sequence exfoliation syndrome gene gene expression profiling gene function gene location gene locus genetic association genetic identification genetic susceptibility genetic variability human intraocular pressure LRP12 gene major clinical study mouse nerve degeneration nonhuman open angle glaucoma optic nerve disease signal transduction single nucleotide polymorphism ZFPM2 gene allele chromosome 8 chromosome 9 exfoliation syndrome genetic association genetics meta analysis metabolism nerve degeneration optic nerve pathology ANRIL long non coding RNA, human ANRIL long non-coding RNA, human homeodomain protein SIX1 protein, human transforming growth factor beta untranslated RNA Alleles Chromosomes, Human, Pair 8 Chromosomes, Human, Pair 9 Exfoliation Syndrome Genome-Wide Association Study Glaucoma, Open-Angle Homeodomain Proteins Humans Nerve Degeneration Optic Nerve Polymorphism, Single Nucleotide RNA, Untranslated Transforming Growth Factor beta 10.1371/journal.pgen.1002654 PLoS Genetics 8 4 e1002654 2019-11-06T09:29:54Z 2019-11-06T09:29:54Z 2012 Article Wiggs J.L., Yaspan B.L., Hauser M.A., Kang J.H., Allingham R.R., Olson L.M., Abdrabou W., Fan B.J., Wang D.Y., Brodeur W., Budenz D.L., Caprioli J., Crenshaw A., Crooks K., DelBono E., Doheny K.F., Friedman D.S., Gaasterland D., Gaasterland T., Laurie C., Lee R.K., Lichter P.R., Loomis S., Liu Y., Medeiros F.A., McCarty C., Mirel D., Moroi S.E., Musch D.C., Realini A., Rozsa F.W., Schuman J.S., Scott K., Singh K., Stein J.D., Trager E.H., VanVeldhuisen P., Vollrath D., Wollstein G., Yoneyama S., Zhang K., Weinreb R.N., Ernst J., Kellis M., Masuda T., Zack D., Richards J.E., Pericak-Vance M., Pasquale L.R., Haines J.L. (2012). Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genetics 8 (4) : e1002654. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1002654 15537390 https://scholarbank.nus.edu.sg/handle/10635/161641 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	animal experiment animal model animal tissue article CDKN2BAS gene chromosome 14q chromosome 8q chromosome 9p controlled study disease association disease classification DNA sequence exfoliation syndrome gene gene expression profiling gene function gene location gene locus genetic association genetic identification genetic susceptibility genetic variability human intraocular pressure LRP12 gene major clinical study mouse nerve degeneration nonhuman open angle glaucoma optic nerve disease signal transduction single nucleotide polymorphism ZFPM2 gene allele chromosome 8 chromosome 9 exfoliation syndrome genetic association genetics meta analysis metabolism nerve degeneration optic nerve pathology ANRIL long non coding RNA, human ANRIL long non-coding RNA, human homeodomain protein SIX1 protein, human transforming growth factor beta untranslated RNA Alleles Chromosomes, Human, Pair 8 Chromosomes, Human, Pair 9 Exfoliation Syndrome Genome-Wide Association Study Glaucoma, Open-Angle Homeodomain Proteins Humans Nerve Degeneration Optic Nerve Polymorphism, Single Nucleotide RNA, Untranslated Transforming Growth Factor beta
spellingShingle	animal experiment animal model animal tissue article CDKN2BAS gene chromosome 14q chromosome 8q chromosome 9p controlled study disease association disease classification DNA sequence exfoliation syndrome gene gene expression profiling gene function gene location gene locus genetic association genetic identification genetic susceptibility genetic variability human intraocular pressure LRP12 gene major clinical study mouse nerve degeneration nonhuman open angle glaucoma optic nerve disease signal transduction single nucleotide polymorphism ZFPM2 gene allele chromosome 8 chromosome 9 exfoliation syndrome genetic association genetics meta analysis metabolism nerve degeneration optic nerve pathology ANRIL long non coding RNA, human ANRIL long non-coding RNA, human homeodomain protein SIX1 protein, human transforming growth factor beta untranslated RNA Alleles Chromosomes, Human, Pair 8 Chromosomes, Human, Pair 9 Exfoliation Syndrome Genome-Wide Association Study Glaucoma, Open-Angle Homeodomain Proteins Humans Nerve Degeneration Optic Nerve Polymorphism, Single Nucleotide RNA, Untranslated Transforming Growth Factor beta Wiggs J.L. Yaspan B.L. Hauser M.A. Kang J.H. Allingham R.R. Olson L.M. Abdrabou W. Fan B.J. Wang D.Y. Brodeur W. Budenz D.L. Caprioli J. Crenshaw A. Crooks K. DelBono E. Doheny K.F. Friedman D.S. Gaasterland D. Gaasterland T. Laurie C. Lee R.K. Lichter P.R. Loomis S. Liu Y. Medeiros F.A. McCarty C. Mirel D. Moroi S.E. Musch D.C. Realini A. Rozsa F.W. Schuman J.S. Scott K. Singh K. Stein J.D. Trager E.H. VanVeldhuisen P. Vollrath D. Wollstein G. Yoneyama S. Zhang K. Weinreb R.N. Ernst J. Kellis M. Masuda T. Zack D. Richards J.E. Pericak-Vance M. Pasquale L.R. Haines J.L. Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
description	10.1371/journal.pgen.1002654
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Wiggs J.L. Yaspan B.L. Hauser M.A. Kang J.H. Allingham R.R. Olson L.M. Abdrabou W. Fan B.J. Wang D.Y. Brodeur W. Budenz D.L. Caprioli J. Crenshaw A. Crooks K. DelBono E. Doheny K.F. Friedman D.S. Gaasterland D. Gaasterland T. Laurie C. Lee R.K. Lichter P.R. Loomis S. Liu Y. Medeiros F.A. McCarty C. Mirel D. Moroi S.E. Musch D.C. Realini A. Rozsa F.W. Schuman J.S. Scott K. Singh K. Stein J.D. Trager E.H. VanVeldhuisen P. Vollrath D. Wollstein G. Yoneyama S. Zhang K. Weinreb R.N. Ernst J. Kellis M. Masuda T. Zack D. Richards J.E. Pericak-Vance M. Pasquale L.R. Haines J.L.
format	Article
author	Wiggs J.L. Yaspan B.L. Hauser M.A. Kang J.H. Allingham R.R. Olson L.M. Abdrabou W. Fan B.J. Wang D.Y. Brodeur W. Budenz D.L. Caprioli J. Crenshaw A. Crooks K. DelBono E. Doheny K.F. Friedman D.S. Gaasterland D. Gaasterland T. Laurie C. Lee R.K. Lichter P.R. Loomis S. Liu Y. Medeiros F.A. McCarty C. Mirel D. Moroi S.E. Musch D.C. Realini A. Rozsa F.W. Schuman J.S. Scott K. Singh K. Stein J.D. Trager E.H. VanVeldhuisen P. Vollrath D. Wollstein G. Yoneyama S. Zhang K. Weinreb R.N. Ernst J. Kellis M. Masuda T. Zack D. Richards J.E. Pericak-Vance M. Pasquale L.R. Haines J.L.
author_sort	Wiggs J.L.
title	Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
title_short	Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
title_full	Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
title_fullStr	Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
title_full_unstemmed	Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
title_sort	common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161641
_version_	1781791809877311488

Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma

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