E-cadherin can limit the transforming properties of activating ?-catenin mutations

• Main Authors: Huels, D.J, Ridgway, R.A, Radulescu, S, Leushacke, M, Campbell, A.D, Biswas, S, Leedham, S, Serra, S, Chetty, R, Moreaux, G, Parry, L, Matthews, J, Song, F, Hedley, A, Kalna, G, Ceteci, F, Reed, K.R, Meniel, V.S, Maguire, A, Doyle, B, Söderberg, O, Barker, N, Watson, A, Larue, L, Clarke, A.R, Sansom, O.J
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: Wiley-VCH Verlag 2020
• Subjects: Wnt protein; beta catenin; cadherin; CTNNB1 protein, mouse; tumor protein; adenomatous polyposis coli gene; animal cell; animal tissue; Article; beta catenin gene; controlled study; crypt cell; crypt progenitor cell; e cadherin gene; gene activation; gene expression regulation; gene loss; gene mutation; genetic transformation; glycogen synthase kinase 3 gene; human; human tissue; in vivo study; intestinal stem cell; mouse; mutator gene; nonhuman; phenotype; priority journal; small intestine; Wnt signaling pathway; animal; cell transformation; colon tumor; genetics; metabolism; mutation; pathology; transgenic mouse; Animals; beta Catenin; Cadherins; Cell Transformation, Neoplastic; Colonic Neoplasms; Mice; Mice, Transgenic; Mutation; Neoplasm Proteins; Wnt Signaling Pathway
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180105
• Institution: National University of Singapore

10.15252/embj.201591739