Development of a conditional liver tumor model by mifepristone-inducible Cre recombination to control oncogenic kras V12 expression in transgenic zebrafish

• Main Authors: Nguyen A.T., Koh V., Spitsbergen J.M., Gong Z.
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: hybrid protein; animal; antibody specificity; cell transformation; disease model; gene expression; gene targeting; gene vector; genetics; homologous recombination; liver cell carcinoma; liver tumor; metabolism; oncogene ras; pathology; signal transduction; transgenic animal; Wnt signaling pathway; zebra fish; Animals; Animals, Genetically Modified; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Disease Models, Animal; Gene Expression; Gene Targeting; Genes, ras; Genetic Vectors; Homologous Recombination; Liver Neoplasms; MAP Kinase Signaling System; Organ Specificity; Recombinant Fusion Proteins; Wnt Signaling Pathway; Zebrafish
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175440
• Institution: National University of Singapore

10.1038/srep19559