The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon

The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon

10.1371/journal.pone.0065964

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Bibliographic Details
Main Authors:	Knudsen M.L., Johansson D.X., Kostic L., Nordström E.K.L., Tegerstedt K., Pasetto A., Applequist S.E., Ljungberg K., Sirard J.-C., Liljeström P.
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Published:	2019
Subjects:	flagellin immunoglobulin G1 immunoglobulin G2 immunoglobulin G2a immunoglobulin G2c immunological adjuvant interferon toll like receptor 5 unclassified drug Alpha virus animal experiment antibody response article controlled study fliC gene innate immunity mouse nonhuman replicon Salmonella typhimurium signal transduction Th1 cell Th2 cell virus recombinant Adjuvants, Immunologic Alphavirus Animals Antibodies, Viral Antigens, Viral Cell Line Cricetinae Flagellin Gene Expression Immunoglobulin G Interferon Type I Mice Mice, Knockout Replicon Signal Transduction Toll-Like Receptor 5 Bacteria (microorganisms) Mus
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161304
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Institution:	National University of Singapore

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Summary:	10.1371/journal.pone.0065964