The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon

• Main Authors: Knudsen M.L., Johansson D.X., Kostic L., Nordström E.K.L., Tegerstedt K., Pasetto A., Applequist S.E., Ljungberg K., Sirard J.-C., Liljeström P.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2019
• Subjects: flagellin; immunoglobulin G1; immunoglobulin G2; immunoglobulin G2a; immunoglobulin G2c; immunological adjuvant; interferon; toll like receptor 5; unclassified drug; Alpha virus; animal experiment; antibody response; article; controlled study; fliC gene; innate immunity; mouse; nonhuman; replicon; Salmonella typhimurium; signal transduction; Th1 cell; Th2 cell; virus recombinant; Adjuvants, Immunologic; Alphavirus; Animals; Antibodies, Viral; Antigens, Viral; Cell Line; Cricetinae; Flagellin; Gene Expression; Immunoglobulin G; Interferon Type I; Mice; Mice, Knockout; Replicon; Signal Transduction; Toll-Like Receptor 5; Bacteria (microorganisms); Mus
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161304
• Institution: National University of Singapore

10.1371/journal.pone.0065964