SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia

• Main Authors: Singh O., Chan J.Y., Lin K., Heng C.C.T., Chowbay B.
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: 2019
• Subjects: breast cancer resistance protein; cytochrome P450 3A5; imatinib; multidrug resistance protein 1; organic cation transporter 1; pregnane X receptor; ABCB1 gene; ABCG2 gene; adult; aged; article; Asian; Chinese; chronic myeloid leukemia; clinical article; clinical trial; CYP3A5 gene; drug blood level; drug clearance; drug concentration; ethnic difference; female; gene linkage disequilibrium; gene sequence; genetic screening; haplotype; human; human experiment; Indian; Malay; male; normal human; nucleotide sequence; pharmacogenetics; plasma trough concentration; prospective study; PXR gene; Singapore; single nucleotide polymorphism; SLC22A1 gene; Adolescent; Adult; Aged; Antineoplastic Agents; Asian Continental Ancestry Group; Benzamides; Female; Haplotypes; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Linkage Disequilibrium; Malaysia; Male; Middle Aged; Organic Cation Transporter 1; P-Glycoprotein; Pharmacogenetics; Piperazines; Polymorphism, Single Nucleotide; Protein Kinase Inhibitors; Pyrimidines; Treatment Outcome; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161358
• Institution: National University of Singapore

10.1371/journal.pone.0051771