SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia
10.1371/journal.pone.0051771
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sg-nus-scholar.10635-1613582023-10-31T08:35:45Z SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia Singh O. Chan J.Y. Lin K. Heng C.C.T. Chowbay B. DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) DUKE-NUS MEDICAL SCHOOL breast cancer resistance protein cytochrome P450 3A5 imatinib multidrug resistance protein 1 organic cation transporter 1 pregnane X receptor ABCB1 gene ABCG2 gene adult aged article Asian Chinese chronic myeloid leukemia clinical article clinical trial CYP3A5 gene drug blood level drug clearance drug concentration ethnic difference female gene linkage disequilibrium gene sequence genetic screening haplotype human human experiment Indian Malay male normal human nucleotide sequence pharmacogenetics plasma trough concentration prospective study PXR gene Singapore single nucleotide polymorphism SLC22A1 gene Adolescent Adult Aged Antineoplastic Agents Asian Continental Ancestry Group Benzamides Female Haplotypes Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive Linkage Disequilibrium Malaysia Male Middle Aged Organic Cation Transporter 1 P-Glycoprotein Pharmacogenetics Piperazines Polymorphism, Single Nucleotide Protein Kinase Inhibitors Pyrimidines Treatment Outcome Young Adult 10.1371/journal.pone.0051771 PLoS ONE 7 12 e51771 2019-11-04T06:32:37Z 2019-11-04T06:32:37Z 2012 Article Singh O., Chan J.Y., Lin K., Heng C.C.T., Chowbay B. (2012). SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia. PLoS ONE 7 (12) : e51771. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0051771 19326203 https://scholarbank.nus.edu.sg/handle/10635/161358 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101 |
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breast cancer resistance protein cytochrome P450 3A5 imatinib multidrug resistance protein 1 organic cation transporter 1 pregnane X receptor ABCB1 gene ABCG2 gene adult aged article Asian Chinese chronic myeloid leukemia clinical article clinical trial CYP3A5 gene drug blood level drug clearance drug concentration ethnic difference female gene linkage disequilibrium gene sequence genetic screening haplotype human human experiment Indian Malay male normal human nucleotide sequence pharmacogenetics plasma trough concentration prospective study PXR gene Singapore single nucleotide polymorphism SLC22A1 gene Adolescent Adult Aged Antineoplastic Agents Asian Continental Ancestry Group Benzamides Female Haplotypes Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive Linkage Disequilibrium Malaysia Male Middle Aged Organic Cation Transporter 1 P-Glycoprotein Pharmacogenetics Piperazines Polymorphism, Single Nucleotide Protein Kinase Inhibitors Pyrimidines Treatment Outcome Young Adult |
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breast cancer resistance protein cytochrome P450 3A5 imatinib multidrug resistance protein 1 organic cation transporter 1 pregnane X receptor ABCB1 gene ABCG2 gene adult aged article Asian Chinese chronic myeloid leukemia clinical article clinical trial CYP3A5 gene drug blood level drug clearance drug concentration ethnic difference female gene linkage disequilibrium gene sequence genetic screening haplotype human human experiment Indian Malay male normal human nucleotide sequence pharmacogenetics plasma trough concentration prospective study PXR gene Singapore single nucleotide polymorphism SLC22A1 gene Adolescent Adult Aged Antineoplastic Agents Asian Continental Ancestry Group Benzamides Female Haplotypes Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive Linkage Disequilibrium Malaysia Male Middle Aged Organic Cation Transporter 1 P-Glycoprotein Pharmacogenetics Piperazines Polymorphism, Single Nucleotide Protein Kinase Inhibitors Pyrimidines Treatment Outcome Young Adult Singh O. Chan J.Y. Lin K. Heng C.C.T. Chowbay B. SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia |
| description |
10.1371/journal.pone.0051771 |
| author2 |
DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) |
| author_facet |
DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) Singh O. Chan J.Y. Lin K. Heng C.C.T. Chowbay B. |
| format |
Article |
| author |
Singh O. Chan J.Y. Lin K. Heng C.C.T. Chowbay B. |
| author_sort |
Singh O. |
| title |
SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia |
| title_short |
SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia |
| title_full |
SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia |
| title_fullStr |
SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia |
| title_full_unstemmed |
SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia |
| title_sort |
slc22a1-abcb1 haplotype profiles predict imatinib pharmacokinetics in asian patients with chronic myeloid leukemia |
| publishDate |
2019 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/161358 |
| _version_ |
1781791745689780224 |