Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling

• Main Authors: Lai J.-G., Tsai S.-M., Tu H.-C., Chen W.-C., Kou F.-J., Lu J.-W., Wang H.-D., Huang C.-L., Yuh C.-H.
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: 2019
• Subjects: antisense oligonucleotide; messenger RNA; phosphatidylinositol 3 kinase; phosphatidylinositol 4 phosphate 3 kinase; protein kinase B; protein kinase WNK1; protein kinase WNK1a; protein kinase WNK1b; unclassified drug; vasculotropin; vasculotropin receptor 2; vasculotropin receptor 3; protein serine threonine kinase; vasculotropin A; VEGFR-2 protein, zebrafish; zebrafish protein; adult; amino acid sequence; angiogenesis; animal experiment; article; controlled study; down regulation; embryo; enzyme activation; enzyme activity; enzyme phosphorylation; female; gene expression regulation; gene silencing; in situ hybridization; intracellular signaling; nonhuman; nucleotide sequence; protein expression; protein function; protein localization; quantitative analysis; reverse transcription polymerase chain reaction; RNA sequence; transcription regulation; transgenic zebrafish; wild type; animal; metabolism; neovascularization (pathology); phosphorylation; physiology; signal transduction; zebra fish; Animals; Neovascularization, Pathologic; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factor Receptor-3; Zebrafish; Zebrafish Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161385
• Institution: National University of Singapore

10.1371/journal.pone.0106129