Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease

• Main Authors: Zupancic T., Stojan J., Lane E.B., Komel R., Bedina-Zavec A., Liovic M.
• Other Authors: PATHOLOGY
• Format: Article
• Published: 2019
• Subjects: claudin 4; cytokeratin 18; cytokeratin 8; protein ZO1; cell extract; amino acid substitution; article; cell function; cell membrane permeability; controlled study; cytokeratin 18 gene; cytokeratin 8 gene; dissociation constant; gene mutation; genetic association; growth rate; heat stress; human; human cell; in vitro study; inflammatory bowel disease; intestine cell; molecular model; permeability barrier; protein localization; cell proliferation; chemical structure; genetics; heat shock response; hydrogen bond; intestine; kinetics; metabolism; mutation; pathology; protein multimerization; protein tertiary structure; tumor cell line; Western blotting; Blotting, Western; Cell Extracts; Cell Line, Tumor; Cell Membrane Permeability; Cell Proliferation; Claudin-4; Heat-Shock Response; Humans; Hydrogen Bonding; Inflammatory Bowel Diseases; Intestines; Keratin-18; Keratin-8; Kinetics; Models, Molecular; Mutation; Protein Multimerization; Protein Structure, Tertiary; Zonula Occludens-1 Protein
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161405
• Institution: National University of Singapore

10.1371/journal.pone.0099398