Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease

10.1371/journal.pone.0099398

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Main Authors: Zupancic T., Stojan J., Lane E.B., Komel R., Bedina-Zavec A., Liovic M.
Other Authors: PATHOLOGY
Format: Article
Published: 2019
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Online Access:https://scholarbank.nus.edu.sg/handle/10635/161405
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spelling sg-nus-scholar.10635-1614052024-04-03T07:38:17Z Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease Zupancic T. Stojan J. Lane E.B. Komel R. Bedina-Zavec A. Liovic M. PATHOLOGY claudin 4 cytokeratin 18 cytokeratin 8 protein ZO1 cell extract claudin 4 cytokeratin 18 cytokeratin 8 protein ZO1 amino acid substitution article cell function cell membrane permeability controlled study cytokeratin 18 gene cytokeratin 8 gene dissociation constant gene mutation genetic association growth rate heat stress human human cell in vitro study inflammatory bowel disease intestine cell molecular model permeability barrier protein localization cell proliferation chemical structure genetics heat shock response hydrogen bond inflammatory bowel disease intestine kinetics metabolism mutation pathology protein multimerization protein tertiary structure tumor cell line Western blotting Blotting, Western Cell Extracts Cell Line, Tumor Cell Membrane Permeability Cell Proliferation Claudin-4 Heat-Shock Response Humans Hydrogen Bonding Inflammatory Bowel Diseases Intestines Keratin-18 Keratin-8 Kinetics Models, Molecular Mutation Protein Multimerization Protein Structure, Tertiary Zonula Occludens-1 Protein 10.1371/journal.pone.0099398 PLoS ONE 9 6 e99398 2019-11-05T00:36:17Z 2019-11-05T00:36:17Z 2014 Article Zupancic T., Stojan J., Lane E.B., Komel R., Bedina-Zavec A., Liovic M. (2014). Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease. PLoS ONE 9 (6) : e99398. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0099398 1932-6203 https://scholarbank.nus.edu.sg/handle/10635/161405 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
topic claudin 4
cytokeratin 18
cytokeratin 8
protein ZO1
cell extract
claudin 4
cytokeratin 18
cytokeratin 8
protein ZO1
amino acid substitution
article
cell function
cell membrane permeability
controlled study
cytokeratin 18 gene
cytokeratin 8 gene
dissociation constant
gene mutation
genetic association
growth rate
heat stress
human
human cell
in vitro study
inflammatory bowel disease
intestine cell
molecular model
permeability barrier
protein localization
cell proliferation
chemical structure
genetics
heat shock response
hydrogen bond
inflammatory bowel disease
intestine
kinetics
metabolism
mutation
pathology
protein multimerization
protein tertiary structure
tumor cell line
Western blotting
Blotting, Western
Cell Extracts
Cell Line, Tumor
Cell Membrane Permeability
Cell Proliferation
Claudin-4
Heat-Shock Response
Humans
Hydrogen Bonding
Inflammatory Bowel Diseases
Intestines
Keratin-18
Keratin-8
Kinetics
Models, Molecular
Mutation
Protein Multimerization
Protein Structure, Tertiary
Zonula Occludens-1 Protein
spellingShingle claudin 4
cytokeratin 18
cytokeratin 8
protein ZO1
cell extract
claudin 4
cytokeratin 18
cytokeratin 8
protein ZO1
amino acid substitution
article
cell function
cell membrane permeability
controlled study
cytokeratin 18 gene
cytokeratin 8 gene
dissociation constant
gene mutation
genetic association
growth rate
heat stress
human
human cell
in vitro study
inflammatory bowel disease
intestine cell
molecular model
permeability barrier
protein localization
cell proliferation
chemical structure
genetics
heat shock response
hydrogen bond
inflammatory bowel disease
intestine
kinetics
metabolism
mutation
pathology
protein multimerization
protein tertiary structure
tumor cell line
Western blotting
Blotting, Western
Cell Extracts
Cell Line, Tumor
Cell Membrane Permeability
Cell Proliferation
Claudin-4
Heat-Shock Response
Humans
Hydrogen Bonding
Inflammatory Bowel Diseases
Intestines
Keratin-18
Keratin-8
Kinetics
Models, Molecular
Mutation
Protein Multimerization
Protein Structure, Tertiary
Zonula Occludens-1 Protein
Zupancic T.
Stojan J.
Lane E.B.
Komel R.
Bedina-Zavec A.
Liovic M.
Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease
description 10.1371/journal.pone.0099398
author2 PATHOLOGY
author_facet PATHOLOGY
Zupancic T.
Stojan J.
Lane E.B.
Komel R.
Bedina-Zavec A.
Liovic M.
format Article
author Zupancic T.
Stojan J.
Lane E.B.
Komel R.
Bedina-Zavec A.
Liovic M.
author_sort Zupancic T.
title Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease
title_short Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease
title_full Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease
title_fullStr Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease
title_full_unstemmed Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease
title_sort intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease
publishDate 2019
url https://scholarbank.nus.edu.sg/handle/10635/161405
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