Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway

• Main Authors: Lu J.-W., Liao C.-Y., Yang W.-Y., Lin Y.-M., Jin S.-L.C., Wang H.-D., Yuh C.-H.
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: 2019
• Subjects: activating transcription factor 6; endothelin 1; fluorescent dye; glycogen; mCherry; microRNA 1; protein IRE1; protein kinase; protein kinase B; protein PERK; RNA; unclassified drug; X box binding protein 1; adult; animal cell; animal experiment; animal model; animal tissue; article; bile duct dilatation; cancer growth; cancer patient; cell culture; cell migration; cell proliferation; controlled study; embryo; fatty liver; gene expression regulation; glycogen metabolism; in vitro study; liver cancer; liver carcinogenesis; liver fibrosis; liver hyperplasia; nonhuman; nucleotide sequence; protein analysis; protein expression; protein function; RNA splicing; signal transduction; tissue specificity; transgenic animal; unfolded protein response; upregulation; xenotransplantation; zebra fish; Animals; Carcinoma, Hepatocellular; Cell Cycle; Cell Movement; Cell Proliferation; Endothelin-1; Fatty Liver; Gene Expression; HEK293 Cells; Humans; Liver Cirrhosis; Liver Neoplasms; MicroRNAs; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Unfolded Protein Response; Zebrafish; Zebrafish Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161437
• Institution: National University of Singapore

10.1371/journal.pone.0085318