Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)

10.1371/journal.pone.0082463

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Main Authors:	Chufan E.E., Kapoor K., Sim H.-M., Singh S., Talele T.T., Durell S.R., Ambudkar S.A.
Other Authors:	PHARMACY
Format:	Article
Published:	2019
Subjects:	5' fluorosulfonylbenzoyl 5' adenosine adenosine derivative adenosine triphosphate cyclosporin A cysteine glutamine membrane protein multidrug resistance protein 1 mutant protein paclitaxel phenylalanine sulfur derivative tariquidar tyrosine unclassified drug valine valinomycin amino acid substitution article baculovirus expression system cell surface controlled study drug binding site drug transport HeLa cell human human cell hydrolysis insect cell mammal cell molecular docking molecular model nonhuman protein aggregation protein domain protein expression residue analysis sequence homology site directed mutagenesis Adenosine Triphosphatases Adenosine Triphosphate Binding Sites Cell Line, Tumor Fluorescent Dyes Gene Expression HeLa Cells Humans Hydrolysis Models, Molecular Molecular Docking Simulation Mutagenesis, Site-Directed P-Glycoprotein Protein Binding Protein Conformation Protein Interaction Domains and Motifs Transduction, Genetic
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161451
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1614512024-11-10T06:31:09Z Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1) Chufan E.E. Kapoor K. Sim H.-M. Singh S. Talele T.T. Durell S.R. Ambudkar S.A. PHARMACY 5' fluorosulfonylbenzoyl 5' adenosine adenosine derivative adenosine triphosphate cyclosporin A cysteine glutamine membrane protein multidrug resistance protein 1 mutant protein paclitaxel phenylalanine sulfur derivative tariquidar tyrosine unclassified drug valine valinomycin amino acid substitution article baculovirus expression system cell surface controlled study drug binding site drug transport HeLa cell human human cell hydrolysis insect cell mammal cell molecular docking molecular model nonhuman protein aggregation protein domain protein expression residue analysis sequence homology site directed mutagenesis Adenosine Triphosphatases Adenosine Triphosphate Binding Sites Cell Line, Tumor Fluorescent Dyes Gene Expression HeLa Cells Humans Hydrolysis Models, Molecular Molecular Docking Simulation Mutagenesis, Site-Directed P-Glycoprotein Protein Binding Protein Conformation Protein Interaction Domains and Motifs Transduction, Genetic 10.1371/journal.pone.0082463 PLoS ONE 8 12 e82463 2019-11-05T02:08:45Z 2019-11-05T02:08:45Z 2013 Article Chufan E.E., Kapoor K., Sim H.-M., Singh S., Talele T.T., Durell S.R., Ambudkar S.A. (2013). Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1). PLoS ONE 8 (12) : e82463. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0082463 1932-6203 https://scholarbank.nus.edu.sg/handle/10635/161451 CC0 1.0 Universal http://creativecommons.org/publicdomain/zero/1.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	5' fluorosulfonylbenzoyl 5' adenosine adenosine derivative adenosine triphosphate cyclosporin A cysteine glutamine membrane protein multidrug resistance protein 1 mutant protein paclitaxel phenylalanine sulfur derivative tariquidar tyrosine unclassified drug valine valinomycin amino acid substitution article baculovirus expression system cell surface controlled study drug binding site drug transport HeLa cell human human cell hydrolysis insect cell mammal cell molecular docking molecular model nonhuman protein aggregation protein domain protein expression residue analysis sequence homology site directed mutagenesis Adenosine Triphosphatases Adenosine Triphosphate Binding Sites Cell Line, Tumor Fluorescent Dyes Gene Expression HeLa Cells Humans Hydrolysis Models, Molecular Molecular Docking Simulation Mutagenesis, Site-Directed P-Glycoprotein Protein Binding Protein Conformation Protein Interaction Domains and Motifs Transduction, Genetic
spellingShingle	5' fluorosulfonylbenzoyl 5' adenosine adenosine derivative adenosine triphosphate cyclosporin A cysteine glutamine membrane protein multidrug resistance protein 1 mutant protein paclitaxel phenylalanine sulfur derivative tariquidar tyrosine unclassified drug valine valinomycin amino acid substitution article baculovirus expression system cell surface controlled study drug binding site drug transport HeLa cell human human cell hydrolysis insect cell mammal cell molecular docking molecular model nonhuman protein aggregation protein domain protein expression residue analysis sequence homology site directed mutagenesis Adenosine Triphosphatases Adenosine Triphosphate Binding Sites Cell Line, Tumor Fluorescent Dyes Gene Expression HeLa Cells Humans Hydrolysis Models, Molecular Molecular Docking Simulation Mutagenesis, Site-Directed P-Glycoprotein Protein Binding Protein Conformation Protein Interaction Domains and Motifs Transduction, Genetic Chufan E.E. Kapoor K. Sim H.-M. Singh S. Talele T.T. Durell S.R. Ambudkar S.A. Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)
description	10.1371/journal.pone.0082463
author2	PHARMACY
author_facet	PHARMACY Chufan E.E. Kapoor K. Sim H.-M. Singh S. Talele T.T. Durell S.R. Ambudkar S.A.
format	Article
author	Chufan E.E. Kapoor K. Sim H.-M. Singh S. Talele T.T. Durell S.R. Ambudkar S.A.
author_sort	Chufan E.E.
title	Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)
title_short	Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)
title_full	Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)
title_fullStr	Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)
title_full_unstemmed	Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)
title_sort	multiple transport-active binding sites are available for a single substrate on human p-glycoprotein (abcb1)
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161451
_version_	1821219395511255040

Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)

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