An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1

• Main Authors: Baskaran, Y, Ang, K.C, Anekal, P.V, Chan, W.L, Grimes, J.M, Manser, E, Robinson, R.C
• Other Authors: PHARMACOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: adenosine triphosphate; Inka1 protein; p21 activated kinase 4; phosphotransferase inhibitor; unclassified drug; Inka protein, human; p21 activated kinase; PAK4 protein, human; protein binding; signal peptide; cells and cell components; crystal structure; enzyme activity; inhibitor; mammal; metazoan; protein; animal cell; Article; controlled study; enzyme active site; human; human cell; nonhuman; protein structure; animal; chemistry; Chlorocebus aethiops; confocal microscopy; COS cell line; crystallization; Escherichia coli; HEK293 cell line; HeLa cell line; immunoprecipitation; in vitro study; metabolism; protein tertiary structure; tumor cell line; X ray crystallography; Mammalia; Metazoa; Adenosine Triphosphate; Animals; Catalytic Domain; Cell Line, Tumor; Cercopithecus aethiops; COS Cells; Crystallization; Crystallography, X-Ray; HEK293 Cells; HeLa Cells; Humans; Immunoprecipitation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Microscopy, Confocal; p21-Activated Kinases; Protein Binding; Protein Structure, Tertiary
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175462
• Institution: National University of Singapore

10.1038/ncomms9681