An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1
10.1038/ncomms9681
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2020
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sg-nus-scholar.10635-1754622024-11-12T01:39:43Z An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 Baskaran, Y Ang, K.C Anekal, P.V Chan, W.L Grimes, J.M Manser, E Robinson, R.C PHARMACOLOGY BIOCHEMISTRY adenosine triphosphate Inka1 protein p21 activated kinase 4 phosphotransferase inhibitor unclassified drug adenosine triphosphate Inka protein, human p21 activated kinase PAK4 protein, human protein binding signal peptide cells and cell components crystal structure enzyme activity inhibitor mammal metazoan protein animal cell Article controlled study crystal structure enzyme active site human human cell nonhuman protein binding protein structure animal chemistry Chlorocebus aethiops confocal microscopy COS cell line crystallization Escherichia coli HEK293 cell line HeLa cell line immunoprecipitation in vitro study metabolism protein tertiary structure tumor cell line X ray crystallography Mammalia Metazoa Adenosine Triphosphate Animals Catalytic Domain Cell Line, Tumor Cercopithecus aethiops COS Cells Crystallization Crystallography, X-Ray Escherichia coli HEK293 Cells HeLa Cells Humans Immunoprecipitation In Vitro Techniques Intracellular Signaling Peptides and Proteins Microscopy, Confocal p21-Activated Kinases Protein Binding Protein Structure, Tertiary 10.1038/ncomms9681 Nature Communications 6 8681 2020-09-10T01:46:48Z 2020-09-10T01:46:48Z 2015 Article Baskaran, Y, Ang, K.C, Anekal, P.V, Chan, W.L, Grimes, J.M, Manser, E, Robinson, R.C (2015). An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1. Nature Communications 6 : 8681. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms9681 20411723 https://scholarbank.nus.edu.sg/handle/10635/175462 Nature Publishing Group Unpaywall 20200831 |
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adenosine triphosphate Inka1 protein p21 activated kinase 4 phosphotransferase inhibitor unclassified drug adenosine triphosphate Inka protein, human p21 activated kinase PAK4 protein, human protein binding signal peptide cells and cell components crystal structure enzyme activity inhibitor mammal metazoan protein animal cell Article controlled study crystal structure enzyme active site human human cell nonhuman protein binding protein structure animal chemistry Chlorocebus aethiops confocal microscopy COS cell line crystallization Escherichia coli HEK293 cell line HeLa cell line immunoprecipitation in vitro study metabolism protein tertiary structure tumor cell line X ray crystallography Mammalia Metazoa Adenosine Triphosphate Animals Catalytic Domain Cell Line, Tumor Cercopithecus aethiops COS Cells Crystallization Crystallography, X-Ray Escherichia coli HEK293 Cells HeLa Cells Humans Immunoprecipitation In Vitro Techniques Intracellular Signaling Peptides and Proteins Microscopy, Confocal p21-Activated Kinases Protein Binding Protein Structure, Tertiary |
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adenosine triphosphate Inka1 protein p21 activated kinase 4 phosphotransferase inhibitor unclassified drug adenosine triphosphate Inka protein, human p21 activated kinase PAK4 protein, human protein binding signal peptide cells and cell components crystal structure enzyme activity inhibitor mammal metazoan protein animal cell Article controlled study crystal structure enzyme active site human human cell nonhuman protein binding protein structure animal chemistry Chlorocebus aethiops confocal microscopy COS cell line crystallization Escherichia coli HEK293 cell line HeLa cell line immunoprecipitation in vitro study metabolism protein tertiary structure tumor cell line X ray crystallography Mammalia Metazoa Adenosine Triphosphate Animals Catalytic Domain Cell Line, Tumor Cercopithecus aethiops COS Cells Crystallization Crystallography, X-Ray Escherichia coli HEK293 Cells HeLa Cells Humans Immunoprecipitation In Vitro Techniques Intracellular Signaling Peptides and Proteins Microscopy, Confocal p21-Activated Kinases Protein Binding Protein Structure, Tertiary Baskaran, Y Ang, K.C Anekal, P.V Chan, W.L Grimes, J.M Manser, E Robinson, R.C An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 |
| description |
10.1038/ncomms9681 |
| author2 |
PHARMACOLOGY |
| author_facet |
PHARMACOLOGY Baskaran, Y Ang, K.C Anekal, P.V Chan, W.L Grimes, J.M Manser, E Robinson, R.C |
| format |
Article |
| author |
Baskaran, Y Ang, K.C Anekal, P.V Chan, W.L Grimes, J.M Manser, E Robinson, R.C |
| author_sort |
Baskaran, Y |
| title |
An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 |
| title_short |
An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 |
| title_full |
An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 |
| title_fullStr |
An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 |
| title_full_unstemmed |
An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 |
| title_sort |
in cellulo-derived structure of pak4 in complex with its inhibitor inka1 |
| publisher |
Nature Publishing Group |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/175462 |
| _version_ |
1821219105043120128 |