Liver-Specific Expressions of HBx and src in the p53 Mutant Trigger Hepatocarcinogenesis in Zebrafish

• Main Authors: Lu J.-W., Yang W.-Y., Tsai S.-M., Lin Y.-M., Chang P.-H., Chen J.-R., Wang H.-D., Wu J.-L., Jin S.-L.C., Yuh C.-H.
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: 2019
• Subjects: glycogen; hepatitis B virus X antigen; mitogen activated protein kinase; Myc protein; protein kinase B; protein p53; protein tyrosine kinase; stress activated protein kinase 1; unclassified drug; vasculotropin; virus antigen; animal experiment; animal model; animal tissue; article; cancer growth; cancer staging; controlled study; drug screening; enzyme activation; enzyme phosphorylation; gene function; gene mutation; glycogen metabolism; in vivo study; lipid metabolism; lipogenesis; liver carcinogenesis; liver cell carcinoma; liver hyperplasia; nonhuman; protein analysis; protein expression; signal transduction; tissue specificity; transgenic animal; upregulation; zebra fish; Animals; Animals, Genetically Modified; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle; Enzyme Activation; Fibrosis; Gene Expression; Glycogen; Humans; Hyperplasia; Lipogenesis; Liver; Liver Neoplasms; Mutation; Neoplasm Metastasis; Organ Specificity; Proliferating Cell Nuclear Antigen; Recombinant Fusion Proteins; Signal Transduction; src-Family Kinases; Trans-Activators; Tumor Markers, Biological; Tumor Suppressor Protein p53; Zebrafish
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161462
• Institution: National University of Singapore

10.1371/journal.pone.0076951