Anti-cadherin-17 antibody modulates beta-catenin signaling and tumorigenicity of hepatocellular carcinoma

• Main Authors: Wang Y., Shek F.H., Wong K.F., Liu L.X., Zhang X.Q., Yuan Y., Khin E., Hu M.-Y., Wang J.H., Poon R.T.P., Hong W., Lee N.P., Luk J.M.
• Other Authors: INSTITUTE OF MOLECULAR & CELL BIOLOGY
• Format: Article
• Published: 2019
• Subjects: antineoplastic agent; beta catenin; cadherin; cadherin 17; cadherin 17 antibody; caspase 8; caspase 9; cisplatin; Lic5 antibody; monoclonal antibody; protein antibody; unclassified drug; Wnt protein; CASP8 protein, human; CASP9 protein, human; CDH17 protein, human; CTNNB1 protein, human; animal cell; animal experiment; animal model; animal tissue; antigen expression; apoptosis; Article; beta catenin signaling; cancer combination chemotherapy; cancer inhibition; cancer model; cancer tissue; carcinogenicity; carcinoma cell; concentration response; controlled study; drug targeting; human; human cell; immunohistochemistry; in vitro study; liver cell carcinoma; lung metastasis; mouse; nonhuman; protein cleavage; randomized controlled trial; subcutaneous tissue tumor; synaptic transmission; tumor xenograft; Western blotting; Wnt signaling; animal; article; Bagg albino mouse; carcinogenesis; drug effect; drug screening; immunology; liver tumor; metabolism; tumor cell line; tumor volume; Wnt signaling pathway; Animals; Antibodies, Monoclonal; Antineoplastic Agents; beta Catenin; Cadherins; Carcinogenesis; Carcinoma, Hepatocellular; Caspase 8; Caspase 9; Cell Line, Tumor; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Tumor Burden; Wnt Signaling Pathway; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161467
• Institution: National University of Singapore

10.1371/journal.pone.0072386