Low expression of DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) correlates with poor prognosis in colorectal cancer

• Main Authors: Yan H., Hu K., Wu W., Li Y., Tian H., Chu Z., Koeffler H.P., Yin D.
• Other Authors: MEDICINE
• Format: Article
• Published: 2019
• Subjects: dual specificity phosphatase; dual specificity tyrosine phosphorylation regulated kinase 2; unclassified drug; Dyrk kinase; messenger RNA; protein serine threonine kinase; protein tyrosine kinase; small interfering RNA; tumor marker; adult; Article; cancer prognosis; cancer staging; cancer survival; cancer tissue; cell invasion; cell migration; cell proliferation; clinical feature; colorectal cancer; colorectal cancer cell line; colorectal carcinoma; controlled study; down regulation; DYRK2 gene; female; gene expression regulation; HCT116 cell line; human; human cell; human tissue; immunohistochemistry; in vitro study; major clinical study; male; overall survival; primary tumor; protein expression; real time polymerase chain reaction; survival time; SW480 cell line; tumor localization; biosynthesis; cell cycle; cell motion; colorectal tumor; disease free survival; genetic database; genetics; HCT 116 cell line; metabolism; middle aged; mortality; RNA interference; treatment outcome; tumor cell line; tumor invasion; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Databases, Genetic; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Male; Middle Aged; Neoplasm Invasiveness; Protein-Serine-Threonine Kinases; Protein-Tyrosine Kinases; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Messenger; RNA, Small Interfering; Treatment Outcome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161560
• Institution: National University of Singapore

10.1371/journal.pone.0159954