Choroidal neovascularization is inhibited in splenic-denervated or splenectomized mice with a concomitant decrease in intraocular macrophage

• Main Authors: Tan X., Fujiu K., Manabe I., Nishida J., Yamagishi R., Terashima Y., Matsushima K., Kaburaki T., Nagai R., Yanagi Y.
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: 2019
• Subjects: beta 3 adrenergic receptor blocking agent; clodronic acid; Ccr2 protein, mouse; chemokine receptor CCR2; Ly antigen; Ly-6C antigen, mouse; adoptive transfer; animal cell; animal experiment; animal model; animal tissue; Article; CD4+ T lymphocyte; CD8+ T lymphocyte; controlled study; denervation; disease course; granulocyte; laser; lymphocyte; macrophage; male; monocyte; mouse; nonhuman; pathogenesis; splenectomy; splenic denervation; subretinal neovascularization; animal; C57BL mouse; cell motion; Choroidal Neovascularization; classification; deficiency; disease model; eye; genetics; immunology; innervation; knockout mouse; metabolism; pathology; spleen; sympathectomy; Adoptive Transfer; Animals; Antigens, Ly; Cell Movement; Disease Models, Animal; Eye; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, CCR2; Spleen; Splenectomy; Sympathectomy
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161562
• Institution: National University of Singapore

10.1371/journal.pone.0160985