Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

10.1371/journal.pntd.0002775

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Main Authors:	Koh C.Y., Kim J.E., Wetzel A.B., de van der Schueren W.J., Shibata S., Ranade R.M., Liu J., Zhang Z., Gillespie J.R., Buckner F.S., Verlinde C.L.M.J., Fan E., Hol W.G.J.
Other Authors:	MEDICINE
Format:	Article
Published:	2019
Subjects:	adenosine triphosphate aminoquinolone based inhibitor antitrypanosomal agent enzyme inhibitor methionine transfer RNA ligase unclassified drug urea based inhibitor African trypanosomiasis aminoacylation article crystal structure drug design drug targeting high performance liquid chromatography IC 50 ligand binding mass spectrometry membrane permeability nuclear magnetic resonance spectroscopy protein expression protein interaction protein purification protein structure site directed mutagenesis synthesis Trypanosoma brucei Antiprotozoal Agents Binding Sites Crystallography, X-Ray Drug Design Enzyme Inhibitors Humans Inhibitory Concentration 50 Methionine-tRNA Ligase Models, Molecular Parasitic Sensitivity Tests Protein Conformation Trypanosoma brucei brucei Urea
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161610
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1616102024-05-08T09:50:48Z Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness Koh C.Y. Kim J.E. Wetzel A.B. de van der Schueren W.J. Shibata S. Ranade R.M. Liu J. Zhang Z. Gillespie J.R. Buckner F.S. Verlinde C.L.M.J. Fan E. Hol W.G.J. MEDICINE adenosine triphosphate aminoquinolone based inhibitor antitrypanosomal agent enzyme inhibitor methionine transfer RNA ligase unclassified drug urea based inhibitor African trypanosomiasis aminoacylation article crystal structure drug design drug targeting high performance liquid chromatography IC 50 ligand binding mass spectrometry membrane permeability nuclear magnetic resonance spectroscopy protein expression protein interaction protein purification protein structure site directed mutagenesis synthesis Trypanosoma brucei Antiprotozoal Agents Binding Sites Crystallography, X-Ray Drug Design Enzyme Inhibitors Humans Inhibitory Concentration 50 Methionine-tRNA Ligase Models, Molecular Parasitic Sensitivity Tests Protein Conformation Trypanosoma brucei brucei Urea 10.1371/journal.pntd.0002775 PLoS Neglected Tropical Diseases 8 4 e2775 2019-11-06T09:24:26Z 2019-11-06T09:24:26Z 2014 Article Koh C.Y., Kim J.E., Wetzel A.B., de van der Schueren W.J., Shibata S., Ranade R.M., Liu J., Zhang Z., Gillespie J.R., Buckner F.S., Verlinde C.L.M.J., Fan E., Hol W.G.J. (2014). Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. PLoS Neglected Tropical Diseases 8 (4) : e2775. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0002775 19352727 https://scholarbank.nus.edu.sg/handle/10635/161610 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	adenosine triphosphate aminoquinolone based inhibitor antitrypanosomal agent enzyme inhibitor methionine transfer RNA ligase unclassified drug urea based inhibitor African trypanosomiasis aminoacylation article crystal structure drug design drug targeting high performance liquid chromatography IC 50 ligand binding mass spectrometry membrane permeability nuclear magnetic resonance spectroscopy protein expression protein interaction protein purification protein structure site directed mutagenesis synthesis Trypanosoma brucei Antiprotozoal Agents Binding Sites Crystallography, X-Ray Drug Design Enzyme Inhibitors Humans Inhibitory Concentration 50 Methionine-tRNA Ligase Models, Molecular Parasitic Sensitivity Tests Protein Conformation Trypanosoma brucei brucei Urea
spellingShingle	adenosine triphosphate aminoquinolone based inhibitor antitrypanosomal agent enzyme inhibitor methionine transfer RNA ligase unclassified drug urea based inhibitor African trypanosomiasis aminoacylation article crystal structure drug design drug targeting high performance liquid chromatography IC 50 ligand binding mass spectrometry membrane permeability nuclear magnetic resonance spectroscopy protein expression protein interaction protein purification protein structure site directed mutagenesis synthesis Trypanosoma brucei Antiprotozoal Agents Binding Sites Crystallography, X-Ray Drug Design Enzyme Inhibitors Humans Inhibitory Concentration 50 Methionine-tRNA Ligase Models, Molecular Parasitic Sensitivity Tests Protein Conformation Trypanosoma brucei brucei Urea Koh C.Y. Kim J.E. Wetzel A.B. de van der Schueren W.J. Shibata S. Ranade R.M. Liu J. Zhang Z. Gillespie J.R. Buckner F.S. Verlinde C.L.M.J. Fan E. Hol W.G.J. Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness
description	10.1371/journal.pntd.0002775
author2	MEDICINE
author_facet	MEDICINE Koh C.Y. Kim J.E. Wetzel A.B. de van der Schueren W.J. Shibata S. Ranade R.M. Liu J. Zhang Z. Gillespie J.R. Buckner F.S. Verlinde C.L.M.J. Fan E. Hol W.G.J.
format	Article
author	Koh C.Y. Kim J.E. Wetzel A.B. de van der Schueren W.J. Shibata S. Ranade R.M. Liu J. Zhang Z. Gillespie J.R. Buckner F.S. Verlinde C.L.M.J. Fan E. Hol W.G.J.
author_sort	Koh C.Y.
title	Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness
title_short	Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness
title_full	Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness
title_fullStr	Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness
title_full_unstemmed	Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness
title_sort	structures of trypanosoma brucei methionyl-trna synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161610
_version_	1800913803233198080

Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

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