Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

10.1371/journal.pntd.0002775

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Bibliographic Details
Main Authors:	Koh C.Y., Kim J.E., Wetzel A.B., de van der Schueren W.J., Shibata S., Ranade R.M., Liu J., Zhang Z., Gillespie J.R., Buckner F.S., Verlinde C.L.M.J., Fan E., Hol W.G.J.
Other Authors:	MEDICINE
Format:	Article
Published:	2019
Subjects:	adenosine triphosphate aminoquinolone based inhibitor antitrypanosomal agent enzyme inhibitor methionine transfer RNA ligase unclassified drug urea based inhibitor African trypanosomiasis aminoacylation article crystal structure drug design drug targeting high performance liquid chromatography IC 50 ligand binding mass spectrometry membrane permeability nuclear magnetic resonance spectroscopy protein expression protein interaction protein purification protein structure site directed mutagenesis synthesis Trypanosoma brucei Antiprotozoal Agents Binding Sites Crystallography, X-Ray Drug Design Enzyme Inhibitors Humans Inhibitory Concentration 50 Methionine-tRNA Ligase Models, Molecular Parasitic Sensitivity Tests Protein Conformation Trypanosoma brucei brucei Urea
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161610
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Institution:	National University of Singapore

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